竞争性内源性RNA在急性髓系白血病中的研究进展

急性髓系白血病 (acute myeloid leukemia, AML) 是多种因素引起的造血系统恶性疾病，具有很高的复发率及死亡率。非编码 RNA在 AML的发生发展过程中发挥着重要作用。竞争性内源性 RNA(competing endogenous RNA, ceRNA)观点指出，不同的非编码 RNA可通过作用于相同的 miRNA反应元件 (MRE)从而调控基因的表达。目前越来越多的研究表明，非编码 RNA作为 ceRNA在调控 AML的增殖、凋亡、侵袭和耐药等生物学过程中发挥关键作用。该文主要对 ceRNA在 AML生物学过程中的调控作用，以及治疗和预后中的临床意义作一综述。

Research Progress of Competitive Endogenous RNA in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system caused by a variety of factors, with a high recurrence rate and mortality rate. Non-coding RNA plays an important role in the occurrence and development of AML. Competing endogenous RNA (ceRNA) point of view points out that different non-coding RNAs can regulate gene expression by acting on the same miRNA response element (MRE). At present, more and more studies have shown that non-coding RNA as ceRNA plays a key role in regulating the biological processes of AML such as proliferation, apoptosis, invasion and drug resistance. This article mainly reviews the regulatory role of non-coding RNA as ceRNA in the biological process of AML, as well as its clinical significance in treatment and prognosis.