高压氧辅助治疗压力性损伤疗效的Meta分析

目的：评价高压氧辅助治疗压力性损伤的疗效。方法：检索CNKI、维普、万方数据库、PubMed、Web of Science、The Cochrane Library自建库到2020年12月使用高压氧辅助治疗压力性损伤的随机对照研究，由2名护理研究生进行文献筛选、信息提取及纳入文献的方法学质量评价，使用RevMan 5.4软件对筛选出的数据进行Meta分析。结果：纳入6项随机对照研究共321例患者，其中162例患者接受压力性损伤传统治疗，设为对照组。另159例患者在对照组治疗基础上联合高压氧治疗，为试验组。Meta分析结果显示，高压氧辅助传统治疗提高了压力性损伤的治愈率RR=0.66,95%CI(0.55,0.80),P<0.001]和总有效率RR=0.20,95%CI(0.10,0.41),P<0.001]，缩短了压力性损伤的愈合时间SMD=-1.99,95%CI(-2.52,-1.47),P<0.001]。结论：在压力性损伤治疗过程中，应用高压氧联合传统治疗比单纯的传统治疗的效果要显著。

Effect of hyperbaric oxygen adjuvant therapy for pressure injuries: a meta-analysis

Objective: To evaluate the effect of hyperbaric oxygen adjuvant therapy for pressure injuries. Methods: CNKI,VIP,WANFANG DATA, PubMed, Web of Science, The Cochrane Library were searched from inception to December 2020 to collect the randomized controlled trials of hyperbaric oxygen adjuvant therapy for pressure injuries. Literature screening, information extraction and methodological quality evaluation of the included literature were conducted by 2 nursing graduates. Meta-analysis was performed on the screened data by RevMan 5.4 software. Results: A total of 321 patients were included in 6 randomized controlled trials, among which 162 patients receiving traditional treatment of pressure injuries were divided into the control group, and 159 patients receiving combined hyperbaric oxygen treatment on the basis of the control group were divided into the experimental group. Meta analysis showed that compared with traditional therapy, hyperbaric oxygen adjuvant therapy improved the cure rate of the pressure injuries RR=0.66, 95% CI(0.55,0.80), P<0.001], the total effective rate RR=0.20, 95% CI(0.10,0.41), P<0.001], and also shortened the healing time (SMD = -1.99, 95% CI(-2.52, -1.47), P＜0.001)]. Conclusion: Hyperbaric oxygen combined with traditional therapy is more effective than traditional therapy alone in the treatment of pressure injuries.