脂质蓄积指数、内脏脂肪指数对2型糖尿病患者一级亲属糖代谢的影响

目的 探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者一级亲属中T2DM及葡萄糖调节受损(impaired glucose regulation,IGR)患者脂质蓄积指数(lipid accumulation product, LAP)、内脏脂肪指数(visceral fat index, VAI)的特征。方法 选取T2DM确诊患者(n=212)一级亲属共298例,依据葡萄糖代谢情况,将研究对象分为葡萄糖代谢正常(normal glucose tolerance,NGT)组(n=115)、IGR组(n=93)、T2DM组(n=90),并收集其临床资料。结果 3组性别差异无统计学意义(P>0.05),3组年龄、身高、体重、体质量指数、腰围差异均有统计学意义(P<0.05),NGT组年龄最小,T2DM组体重、腰围最大(均P<0.05)。NGT组、IGR组、T2DM组中心性肥胖发生率分别为52.17%、67.74%和78.88%,其中T2DM组肥胖率最高,T2DM组、IGR组的中心性肥胖率较NGT组高(均P<0.05)。3组LAP、VAI差异均有统计学意义(P<0.05),T2DM组LAP最高,NGT组VAI最高(均P<0.05)。LAP、VAI是T2DM患者患有T2DM一级亲属糖化血红蛋白的独立影响因素,LAP是T2DM患者患有IGR一级亲属口服葡萄糖耐量试验2 h血糖的独立影响因素。结论 T2DM患者一级亲属中糖尿病及糖尿病前期患者的中心性肥胖率明显增加,其中新型体脂指标LAP、VAI是T2DM患者一级亲属葡萄糖代谢紊乱的重要影响因子。

Correlation analysis between lipid accumulation index and visceral fat index and glucose metabolism disorders in first-degree relatives of type 2 diabetes mellitus

Objective To investigate the characteristics of lipid accumulation product (LAP) and visceral fat index (VAI) in first-degree relatives of patients with type 2 diabetes mellitus (T2DM) who were impaired glucose regulation (IGR).Methods Totally 212 patients were as subjects among 298 first-degree relatives of T2DM. The clinical data were assessed in the three groups which comprised 115 (normal glucose tolerance, NGT), 93 (impaired glucose regulation, IGR), and 90 (T2DM) patients. Results There was no significant gender difference among the three groups (P>0.05), but differences in age, height, weight, body mass index, and waist circumference among the three groups were all statistically significant (P<0.05). The NGT group was the youngest, and the T2DM group had the largest weight and waist circumference (all P<0.05). The incidence of central obesity in NGT group, IGR group, and T2DM group were 52.17%, 67.74%, and 78.88%, respectively, and the obesity rate in T2DM group was the highest, and the central obesity rate in T2DM group and IGR group was significantly higher than that in NGT group (all P<0.05). There were statistically significant differences in LAP and VAI among the three groups (P<0.05). The T2DM group had the highest LAP and the NGT group had the highest VAI (all P<0.05). LAP and VAI were independent influencing factors for glycated hemoglobin in first-degree relatives of T2DM patients, and LAP was an independent influencing factor for 2-hour blood glucose.Conclusion The central obesity rate in first-degree relatives of T2DM and prediabetes is significantly increased, and the new indexes of LAP and VAI are important influencing factors for glucose metabolic disorders of these patients.