监测外周血中性粒细胞胞外诱捕网含量对食管癌远处转移的预测价值

目的 评价中性粒细胞胞外诱捕网（NET）生成对食管癌远处转移的预测价值。方法 前瞻性纳入食管癌患者（远处转移25例、非远处转移35例）和30名健康志愿者，检测其外周血NET含量并进行分析。结果 食管癌远处转移者外周血NET含量高于非远处转移者和健康志愿者。外周血NET含量升高是食管癌远处转移的独立危险因素（OR=1049.592, 95%CI:24.313～45310.558）。监测NET含量可预测食管癌的远处转移（AUC=0.37, 95%CI:0.737～0.937），其预测价值高于中性粒细胞与淋巴细胞比值（NLR）;NET联合NLR可以提高NET预测食管癌远处转移的灵敏度和特异度。结论 NET生成是食管癌远处转移的高危因素，监测外周血NET的含量可预测食管癌远处转移，NET联合NLR能够提高NET的预测价值。

Value of neutrophil extracellular trap formation in predicting esophageal cancer distant metastasis

Objective To investigate the value of neutrophil extracellular trap （NET） formation in predicting esophageal cancer distant metastasis. Methods A total of 60 patients diagnosed with esophageal cancer （25 cases of distant metastasis and 35 cases of non-distant metastasis） and 30 healthy volunteers were included in this prospective study. Peripheral blood was collected to detect the level of NET. Results The level of NET in the peripheral blood of patients with esophageal cancer distant metastasis was higher than those of their counterparts without distant metastasis and healthy volunteers. Logistic regression analysis showed that increased peripheral blood NET content was an independent risk factor for esophageal cancer distant metastasis （OR=1049.592, 95%CI： 24.313-45310.558）. Monitoring NET content could predict distant metastasis of esophageal cancer （AUC=0.37, 95%CI： 0.737-0.937）, and its predictive value was higher than that of the neutrophil-to-lymphocyte ratio （NLR）. However, the combination of NET and NLR improved the sensitivity and specificity of NETs in predicting esophageal cancer distant metastasis. Conclusions NET formation is a high risk factor for distant metastasis of esophageal cancer. Monitoring NET in the peripheral blood yields high predictive value for esophageal cancer distant metastasis. NETs combined with NLR can improve the predictive value of NET.