Elevated inflammatory markers in preeclamptic pregnancies,but no relation to systemic arterial stiffness |
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| Affiliation: | 1. National Resource Center for Women’s Health, Oslo University Hospital Rikshospitalet, Oslo, Norway;2. Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway;3. Department of Anaesthesiology, Oslo University Hospital Rikshospitalet, Oslo, Norway;4. Institute for Surgical Research, Oslo University Hospital Rikshospitalet, Oslo, Norway;5. Section of Specialized Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway;6. Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway;7. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;8. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway;9. Faculty of Medicine, University of Oslo, Oslo, Norway;10. K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway;11. K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway;1. Department of Maternity Services, Royal Women’s Hospital, Cnr Flemington Rd and Grattan St, Parkville 3053, Australia;2. Department of Statistical Risk Management, KPMG, 147 Collins St, Melbourne 3000, Australia;3. Department of Obstetrics and Gynecology, University of Melbourne, Australia;1. University of Vermont, Department of Obstetrics, Gynecology and Reproductive Sciences, Burlington, VT 05405, United States;2. University of Vermont, Department of Medical Biostatistics, Burlington, VT 05405, United States;3. University of Vermont, Department of Pediatrics, Burlington, VT 05405, United States;4. Vermont Oxford Network, Burlington, VT 05401, United States;1. Department of Obstetrics & Gynecology, Affiliated Hospital, Logistical College of Chinese People’s Armed Police Forces, Tianjin 300162, PR China;2. Maternity & Children Hospital of Northwest District, Shaanxi, Xi’an 710003, PR China;3. Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Shaanxi, Xi’an 710033, PR China;1. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada;2. Department of Obstetrics and Gynaecology, Kingston General Hospital, Kingston, ON, Canada;1. Second Department of Obstetrics & Gynecology, Medical School, University of Athens “Aretaieio” Hospital, Athens, Greece;2. “EmbryoCare”, Fetal Medicine Unit, Athens, Greece;3. “Diamedica SA”, Clinical Chemistry Laboratory, Athens, Greece;4. Department of Midwifery, Faculty of Health and Caring Professions, Technological Educational Institute of Athens, Athens, Greece;5. Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, University of Athens, Athens, Greece;6. Hormone Laboratory, “Aretaieio” Hospital, Athens, Greece;1. Department of Obstetrics and Gynecology, Rowan University – School of Osteopathic Medicine, Stratford, NJ, United States;2. Department of Obstetrics and Gynecology, Yale University – School of Medicine, OB/GYN, New Haven, CT, United States;3. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, United States |
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| Abstract: | ObjectivesTo investigate if circulating markers of systemic and vascular inflammation are associated with systemic arterial properties at term and 6 months post-partum in women with preeclampsia (PE) and normal pregnancy (NP).Study designLongitudinal, sampling at term and 6 months post-partum in 34 women (32 ± 6 years) with PE and 61 women (32 ± 5 years) with NP.Main outcome measuresCirculating markers related to systemic and vascular inflammation were measured by enzyme immune-assay. Systemic arterial properties were estimated by Doppler (transthoracic echocardiography) and calibrated right subclavian artery pulse traces.ResultsCXCL16, soluble tumor necrosis factor receptor type 1 (sTNF-R1), monocyte chemoattractant peptide 1, pentraxin 3 and soluble vascular adhesion molecule 1 (sVCAM-1) were elevated at term in PE, and sTNF-R1 remained elevated 6 months post partum compared to NP. However, apart from a negative correlation between mean arterial pressure and sTNF-R1 and sVCAM-1 at term, no associations between systemic and vascular inflammatory markers and systemic arterial properties as reflected by characteristic impedance and arterial elastance, representing proximal aortic stiffness and effective arterial elastance, were found at any time point.ConclusionsPreeclamptic pregnancies are characterized by increased circulating levels of systemic and vascular inflammatory markers. However, these are not associated with systemic arterial properties at term or 6 months post partum. |
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| Keywords: | Inflammation Pregnancy Preeclampsia Arterial stiffness |
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