系统性红斑狼疮患者血清IL-1家族多种细胞因子、拮抗剂及可溶性受体水平表达与疾病活动度的相关性研究

目的 分析系统性红斑狼疮(systemic lupus erythematosus,SLE)病人血清中IL-1家族细胞因子、拮抗剂与可溶性受体含量变化与临床价值.方法 选取泸州市中医医院于2018年6月～2020年6月期间收治的60例SLE病人为观察组,同期60例健康体检人员为对照组,另基于SLE疾病活动指数评分(SL...

Correlation between Serum IL-1 Family Cytokines,Antagonists and Soluble Receptors and Disease Activity in Patients with Systemic Lupus Erythematosus

Objective　To analyze the changes and clinical value of IL-1 family cytokines, antagonists and soluble receptors in systemic lupus erythematosus（SLE） patients. Methods　Selected a total of 60 SLE patients treated in the Luzhou Traditional Chinese Medicine Hospital from June 2018 to June 2020 as the observation group , while subjects in the control group were 60 healthy physical examination personnel in the same period. In addition, based on SLEDAI , the observation group was divided into the active group and the inactive group. The contents of IL-1 family cytokines, antagonists and soluble receptors in the above three groups were compared, and the correlation between the levels of cytokines in SLE patients and immune indexes ds-DNA, complement C3, C4 and C1q was analyzed. Results　 There were significant differences in cytokines IL-331.5(0~2.90) vs 0.2(0~1.46)]pg/ml, IL-18
329.2(271.5~386.2) vs 430.0(314.6~587.8)]pg/ml, antagonists IL-18BP
6 455（5 021~8 357） vs 9 863(6 982~15 746)]pg/ml, IL- 1Ra173.5(120.3~213.8) vs 226.9(129.9~ 478.2)]pg/ml and soluble receptor IL-1R41 004(7 356~12 553) vs 15 870（12 336 ~ 23 569）]pg/ml between the observation group and the control group (t = 7.446，8.513，10.256，5.864，12.257， all P < 0.05). There was a correlation between cytokines IL-18, freeIL-18, IL-1R2, IL-1R4 and multiple autoantibodies or complements in SLE patients (r=-0.328~0.412，all P < 0.05). The levels of IL-18, free IL-18 and IL-1R4 cytokines in SLE active group were significantly higher than those in stable group (all P < 0.05). Conclusion　IL-18 and IL-1R4 may be candidate biomarkers for predicting disease activity in SLE patients．