上皮性卵巢癌组织中miR-506-3p及miR-532-5p的表达与临床病理特征及预后的相关研究

目的 探讨miR-506-3p及miR-532-5p在上皮性卵巢癌（epithelial ovarian cancer,EOC）组织中的表达及其对预后预测的意义。方法 选取2017年1月～2019年12月三亚市妇女儿童医院和三亚中心医院收治的118例EOC患者。检测EOC组织及正常组织中miR-506-3p及miR-532-5p表达水平。应用单因素及多因素COX回归模型分析EOC患者预后不良的危险因素。结果 EOC组织miR-506-3p(0.31±0.05)及miR-532-5p(0.24±0.03)表达水平低于正常组织（1.16±0.42,1.48±0.51），差异有统计学意义（t=13.582,16.217，均P<0.001）。Kaplan-Meier生存分析显示，miR-506-3p及miR-532-5p低表达与EOC患者生存期短有关（P<0.001）。多因素分析显示，淋巴结转移[HR(95%CI)=1.840(1.137～4.105)]，腹膜转移[HR(95%CI)=2.974(2.106～6.113)],miR-506-3p <0.45[HR(95%CI)...

Correlation between the Expression of miR-506-3p and miR-532-5p and Clinicopathological Features and Prognosis in Epithelial Ovarian Cancer

Objective　To investigate the expression of miR-506-3p and miR-532-5p in epithelial ovarian cancer (EOC) and its prognostic significance. Methods　The 118 patients with EOC admitted to Sanya Woman and Children’s Hospital and Sanya Central Hospital from January 2017 to December 2019 were selected. The expression levels of miR-506-3p and miR- 532-5p in EOC and normal tissues were detected. Univariate and multivariate COX regression models were used to analyze the risk factors of poor prognosis in EOC patients. Results　The expression level of miR-506-3p (0.31±0.05 ) and miR-532- 5p (0.24±0.03 ) in EOC were lower than that in normal tissues(1.16±0.42，1.48±0.51 )，the differences were statistically significant (t=13.582, 16.217, all P<0.001). Kaplan-Meier survival analysis showed that low expression of miR-506-3p and miR- 532-5p were associated with short survival of EOC patients (P<0.001). Multivariate Cox regression analysis showed that lymph node metastasis[HR（95%CI）=1.840（1.137 ～ 4.105）], peritoneal metastasis[HR（95%CI）=2.974（2.106 ～ 6.113）], miR-506-3p<0.45 [HR（95%CI）=1.902（1.217 ～ 4.533）]and miR-532-5p<0.32[HR（95%CI）=2.506（1.582 ～ 4.905）] were independent risk factors for poor prognosis of EOC patients (all P<0.05). Conclusion　miR-506-3p and miR-532-5p were significantly down-regulated in EOC tissues, and the survival time of EOC patients with low expression of miR-506-3p was shorter, which had a good value for predicting the prognosis of EOC patients.