振幅整合脑电图与窒息新生儿桡动脉血气分析和头颅MRI的相关性

目的：探讨窒息新生儿振幅整合脑电图(aEEG)检查结果与桡动脉血气分析和头颅MRI检查结果的相关性。方法：回顾性研究确诊为新生儿窒息的50例患儿的临床资料，分析不同窒息程度与aEEG异常程度、睡眠-觉醒周期情况和有无痫样活动之间的相关性；分析aEEG异常程度与桡动脉血气结果以及MRI异常程度的相关性。结果：患儿窒息程度与aEEG异常程度、睡眠-觉醒周期情况、有无痫样活动均呈正相关(P<0.05)；不同aEEG异常程度的患儿之间，pH、氧分压(PO₂)、二氧化碳分压(PCO₂)、碱剩余(BE)水平均有显著差异(P<0.05),aEEG正常组PCO₂水平显著低于aEEG轻度异常组(P<0.05),BE水平显著高于aEEG轻度异常组(P<0.05),aEEG正常组和aEEG轻度异常组pH、PO₂和BE水平均显著高于aEEG重度异常组，PCO₂水平则显著低于aEEG重度异常组，差异有统计学意义(P<0.05)；患儿aEEG异常程度与MRI异常程度呈正相关(...

Correlations of amplitude-integrated electroencephalogram with radial artery blood gas analysis and cranial MRI in asphyxiated newborns

Abstract: Objective To investigate the correlations of amplitude-integrated electroencephalogram (aEEG) with radial artery blood gas analysis and cranial MRI in newborns with asphyxia. Methods The clinical data of 50 children with neonatal asphyxia were analyzed retrospectively. The correlations of different asphyxia degrees with the degree of aEEG abnormality, sleep-wake cycle and epileptiform activity were analyzed. In addition, the correlations of the degree of aEEG abnormality with the results of radial artery blood gas analysis and the degree of MRI abnormality were studied. Results The degree of asphyxia was positively correlated with the degree of aEEG abnormality, sleep-wake cycle and epileptiform activity (P<0.05). There were significant differences in pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2) and base excess (BE) between children with different degrees of aEEG abnormality (P<0.05). Compared with those in mild abnormal aEEG group, the PCO2 level in normal aEEG group was significantly lower (P<0.05), and the BE level was significantly higher (P<0.05). The pH, PO2 and BE levels in normal aEEG group and mild abnormal aEEG group were significantly higher than those in severe abnormal aEEG group, but the PCO2 level in severe abnormal aEEG group was significantly higher that in the other groups (P<0.05). There was a positive correlation between degree of aEEG abnormality and degree of MRI abnormality (P<0.05). Conclusion The aEEG examination result of asphyxiated newborns is closely related to the results of radial artery blood gas analysis and cranial MRI, and therefore can be used for the ultra-early diagnosis of asphyxia in newborns.