中国人尿酸水平与急性缺血性脑卒中患者预后关系的meta分析

目的 采用meta分析方法全面系统的评价中国人尿酸水平与急性缺血性脑卒中患者预后的关系。方法 通过计算机系统检索PubMed、Web of Science、Embase、Cochrane Library、中国知网、维普和万方数据库，收集有关中国人尿酸水平与急性缺血性脑卒中患者预后关系的病例对照研究，检索时限为从各数据库建库至2022年2月。采用STATA 16软件进行meta分析。结果 共纳入13篇文献，共计11 046例研究对象，其中预后良好组8 016例，预后不良组3 030例。结果显示，预后良好组尿酸水平高于预后不良组[WMD=18.44μmol/L,95%CI(3.20,33.68),P<0.05]。敏感性分析和发表偏倚检验结果表明本研究结果稳定、可靠。结论 中国人尿酸水平与急性缺血性脑卒中患者的预后可能相关，并且预后良好的患者尿酸水平更高，提示尿酸水平较高的中国急性缺血性脑卒中患者可能预后功能更好。

Relationship between uric acid and prognosis of Chinese patients with acute ischemic stroke: A meta analysis

Objective The meta analysis method was applied to comprehensively and systematically evaluate relations between uric acid and prognosis of Chinese patients with acute ischemic stroke.Methods PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP and Wanfang databases were searched by computer system to collect case-control studies on relation between the level of uric acid and prognosis of patients with acute ischemic stroke in Chinese from database establishment to February 2022. The Meta analysis was performed using STATA 16 software. Results Thirteen literatures representing a total of 11, 046 study subjects (n=8, 016 in the good prognosis group, and n=3 030 in the poor prognosis group) were included in the meta-analysis. The results showed that the uric acid level of patients in the good prognosis group was higher than that of poor prognosis group [WMD=18.44 μmol/L, 95%CI(3.20, 33.68), P<0.05]. The results of sensitivity analysis and publication bias test showed that the study results were stable and reliable.Conclusion The level of uric acid in Chinese may be related to the prognosis of patients with acute ischemic stroke, and the higher level of uric acid in Chinese patients may have a better prognosis.