| lncRNA减轻心肌缺血再灌注损伤的研究进展 |
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| 引用本文： | 成姣,谢佳欣,刘晨,黄骥,韦星.lncRNA减轻心肌缺血再灌注损伤的研究进展[J].中国动脉硬化杂志,2023,31(6):539-545. |
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| 作者姓名： | 成姣 谢佳欣 刘晨 黄骥 韦星 |
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| 作者单位： | 南华大学心血管疾病研究所 动脉硬化学湖南省重点实验室 湖南省动脉硬化性疾病国际科技创新合作基地,湖南省衡阳市 421001 |
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| 基金项目： | 国家自然科学基金项目(82100789)；湖南省教育厅科学研究重点项目(19A432) |
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| 摘 要： | 长链非编码RNA(lncRNA)是一类长度大于200个核苷酸且无蛋白质编码能力的RNA,但在增殖、凋亡、迁移、侵袭和分化等多种生物过程中起着非常重要的调节作用。研究发现lncRNA与心肌缺血再灌注(I/R)损伤的发生发展密切相关。本综述讨论了lncRNA减少心肌I/R损伤及其可能机制的研究进展。
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| 关 键 词： | 长链非编码RNA 心肌缺血再灌注损伤 氧化应激 自噬 炎症反应 细胞凋亡 |
| 收稿时间： | 2022/10/14 0:00:00 |
| 修稿时间： | 2022/12/26 0:00:00 |
Developments in lncRNA reducing myocardial ischemia/reperfusion injury |
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| CHENG Jiao,XIE Jiaxin,LIU Chen,HUANG Ji,WEI Xing.Developments in lncRNA reducing myocardial ischemia/reperfusion injury[J].Chinese Journal of Arteriosclerosis,2023,31(6):539-545. |
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| Authors: | CHENG Jiao XIE Jiaxin LIU Chen HUANG Ji WEI Xing |
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| Institution: | Institute of Cardiovascular Diseases, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Scientific and Technological Innovation Cooperation Base for Arteriosclerotic Diseases in Hunan Province, Hengyang, Hunan 421001, China |
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| Abstract: | Long non-coding RNA (lncRNA) is a class of RNA more than 200 nucleotides long and has no protein-coding capacity, but it plays a very important role in regulating various biological processes such as proliferation, apoptosis, migration, invasion and differentiation. It has found that lncRNA is closely related to the development of myocardial ischemia/reperfusion (I/R) injury. This review discusses the advances in the reduction of myocardial I/R injury and its possible mechanisms by lncRNA. |
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| Keywords: | long non-coding RNA myocardial ischemia/reperfusion injury oxidative stress autophagy inflammatory response apoptosis |
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