| CRISPR/Cas系统在新型冠状病毒肺炎快速诊断中的应用 |
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| 引用本文： | 吴永彬1,李 凌2. CRISPR/Cas系统在新型冠状病毒肺炎快速诊断中的应用[J]. 现代检验医学杂志, 2022, 0(3): 1-5. DOI: 10.3969/j.issn.1671-7414.2022.03.001 |
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| 作者姓名： | 吴永彬1 李 凌2 |
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| 作者单位： | （1. 广西壮族自治区南溪山医院检验科, 广西桂林 541002； 2. 南方医科大学基础医学院，广州 510515） |
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| 摘 要： | 近年来，基于规律成簇间隔的短回文重复序列（ clustered regularly interspaced short palindromic repeats, CRISPR）及其相关蛋白（ CRISPR-associated protein, Cas）系统的新型分子诊断工具，为病原体的诊断开辟了新的机遇。该文将关注现有和正在研究的 CRISPR/Cas系统用于新型冠状病毒肺炎（coronavirus disease 2019, COVID-19）快速诊断的潜在能力，并重点探讨其在临床中的应用和面临的挑战。
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| 关 键 词： | 间隔的短回文重复序列及其相关蛋白系统 新型冠状病毒 新型冠状病毒肺炎 快速诊断 |
Application of CRISPR/Cas Systems in the Rapid Diagnosis of Coronavirus Disease 2019 |
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| WU Yong-bin1,LI Ling2. Application of CRISPR/Cas Systems in the Rapid Diagnosis of Coronavirus Disease 2019[J]. Journal of Modern Laboratory Medicine, 2022, 0(3): 1-5. DOI: 10.3969/j.issn.1671-7414.2022.03.001 |
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| Authors: | WU Yong-bin1 LI Ling2 |
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| Affiliation: | (1. Department of Laboratory Medicine, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guangxi Guilin 541002, China; 2. School of Basic Medicine, Southern Medical University, Guangzhou 510515, China) |
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| Abstract: | In recent years, emerging molecular diagnostic tools based on clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) systems have opened up new opportunities for pathogen diagnosis. This article will focus on the potential capabilities of the existing and under-research CRISPR/Cas systems for rapid diagnosis of the coronavirus disease 2019 (COVID-19), and discuss their clinical applications and challenges. |
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