髓系抑制性细胞在肝癌发病中的作用研究进展

髓系抑制性细胞（MDSCs）是备受关注的免疫抑制性细胞，具有调节免疫应答的作用。近年发现MDSCs与肝癌发生发展及预后密切相关，肝癌微环境中多种因子影响MDSCs的扩增、活化和募集，而MDSCs通过下调机体的抗肿瘤免疫应答或诱导免疫耐受形成，促进肿瘤的生长与转移。研究MDSCs在肝癌免疫逃逸的作用，将为肝癌早期发现、诊断及免疫治疗等提供新线索。

Advances in the role of myeloid derived suppressor cells in the pathogenesis of hepatocellular carcinoma

Myeloid derived suppressor cells (MDSCs) are immunosuppressor cells that have attracted much attentionand play a role in regulating immune response. Recently, accumulating evidence has demonstrated that MDSCs are closely related to the development and prognosis of hepatic cancer. Multiple factors in the microenvironment of hepatic cancer affect the expansion, activation and recruitment of MDSCs, while MDSCs promote tumor growth and metastasis by downregulating antitumor immune response or inducing immune tolerance. The study on effect of MDSCs on immune escape of hepatic cancer will provide new clues for early detection, diagnosis and immunotherapy of hepatic cancer.