卡拉胶寡糖对放射损伤的防护作用

目的 探讨卡拉胶寡糖对受6．0Gy X射线照射小鼠的辐射防护作用。方法采用6MV X直线加速器一次全身照射BALB／c小鼠，3个卡拉胶寡糖组照射前连续14d和照射后继续给药7d。观察小鼠30d存活率、外周血白细胞总数、胸腺指数和脾脏指数、脾脏NK细胞活性和腹腔巨噬细胞吞噬功能。结果卡拉胶寡糖组小鼠30d存活率比照射对照组提高75％～90％；而且卡拉胶寡糖能加速小鼠外周血白细胞的恢复，明显提高胸腺指数和脾脏指数，激活脾脏NK细胞的杀伤活性，增强巨噬细胞吞噬功能。结论卡拉胶寡糖对受照射小鼠有明显的辐射防护作用。

Radioprotective effect of carrageenan-derived oligosaccharides on mice with radiation injury

Objective To study the radioprotection effect of the carrageenan-derived oligosaccharides on irradiated mice. Methods The carrageenan-derived oligosaccharides were applied to BALB/c mice daily for successive 14 days before whole-body irradiation with 6.0 Gy X-rays and for 7 days after the irradiation.The 30-day survival rate,counts of peripheral white blood cells,thymus and spleen index,cytostatic activity of NK,and peritoneal macrophage phagocytosis were studied. Results The 30-day survival rate elevated from 75% in the control group to 90% in the oligosaccharides-treated group.The carrageenan-derived oligosaccharides significantly promoted recovery of peripheral white blood cells,markedly increased thymus and spleen index,NK cytostatic activity and peritoneal macrophage phagocytosis. Conclusion The carrageenan-derived oligosaccharides has marked radioprotective effect on irradiated mice.;