| 药物代谢研究与中药现代化 |
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| 引用本文： | 冯年平,狄斌,刘文英.药物代谢研究与中药现代化[J].世界科学技术,2003,5(2):5-7. |
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| 作者姓名： | 冯年平 狄斌 刘文英 |
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| 作者单位： | [1]上海中医药大学,上海200032 [2]中国药科大学,南京210009 |
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| 基金项目： | 上海市教委、上海市教育发展基金会"上海市曙光计划2001年项目(01SG51)":中药复方代谢分析方法研究,负责人:冯年平. |
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| 摘 要： | 药物代谢过程是影响药物发挥作用及产生毒性的过程。中药的配伍变化会直接导致药效成分在体内的代谢发生变化。运用LC／MS^n等现代分析技术手段进行中药复方代谢研究,对于中药现代化有重要意义：研究中药复方体内代谢特征,探索中药复方的作用机制和配伍原理;通过体内代谢过程研究,寻找新的治疗药物;为中药新型给药系统的研究开发提供依据。
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| 关 键 词： | 药物代谢 中药现代化 治疗药物 药物配伍 |
| 修稿时间： | 2003年1月12日 |
Drug Metabolism and Modernization of Traditional Chinese Medicine |
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| Feng Nianping.Drug Metabolism and Modernization of Traditional Chinese Medicine[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2003,5(2):5-7. |
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| Authors: | Feng Nianping |
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| Abstract: | The process of drug metabolism is such which may exert influence on the development of the effectiveness and the production of the toxicity of drugs. The change of the compatibility of traditional Chinese medicines may lead directly to the change of the metabolism of drug effectiveness in human body. Therefore, the investigation of the metabolism of compound Chinese drugs by modern analytical techniques, such as LC/MSn, may play important roles as follows in the modernization of traditional Chinese medicine: to study the characteristics of in vivo metabolism and explore the functional mechanisms and compatibility principles of compound Chinese drugs; to find new drugs by the study of the process of in vivo metabolism; and to provide scientific basis for the research and development of new administration systems of Chinese drugs. |
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| Keywords: | drug metabolism modernization of traditional Chinese medicine pharmacokinetics |
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