The Effect of Dry Cleared Extract from Licorice Roots on the Learning of Ovariectomized Rats

The influence of chronic administration of a dry cleared extract of Glycyrrhiza glabra (DCEG) containing flavonoids on the behavioral status and learning of intact and ovariectomized adult female rats has been studied. The DCEG preparation was administered in low (0.5 mg/kg, i.p.) and high (5.0 mg/kg, i.p.) daily doses over a period of 14 days and the results were evaluated on the passive avoidance situation model and in the open field test. It was established that the chronic administration of DCEG in both low and high doses produced correction of the passive avoidance performance in ovariectomized female rats. The administration of DCEG in a low dose also positively influenced the structure of purposeful behavior of females with deficiency of estrogens. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 8, pp. 27 – 29, August, 2005.