Parental smoking,maternal alcohol,coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE,France) |
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| Authors: | Helen D. Bailey Brigitte Lacour Léa Guerrini-Rousseau Anne-Isabelle Bertozzi Pierre Leblond Cécile Faure-Conter Isabelle Pellier Claire Freycon François Doz Stéphanie Puget Stéphane Ducassou Laurent Orsi Jacqueline Clavel |
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| Affiliation: | 1.INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l’enfant et de l’adolescent,Paris,France;2.RNCE - National Registry of Childhood Cancers, Inserm, Villejuif and CHU de Nancy,Villejuif,France;3.Département de cancérologie de l’enfant et de l’adolescent, Gustave Roussy,Villejuif,France;4.Unité d’ Hémato-Immuno-Oncologie pédiatrique, P?le Pédiatrique, CHU Toulouse,Toulouse,France;5.Pediatric Oncology Unit, Oscar Lambret Comprehensive Cancer Center,Lille,France;6.Institut d’hématologie et d’oncologie pédiatrique, IHOPe, Centre Léon Bérard,Lyon,France;7.Hématologie Oncologie et Immunologie pédiatrique, Inserm UMR U1232, CHU d’Angers,Angers,France;8.Clinique de pédiatrie, H?pital Couple Enfant, CHU Grenoble-Alpes,Grenoble,France;9.Département de Pédiatrie -Adolescents et Jeunes Adultes, Institut Curie, et Université Paris Descartes, Paris,Paris,France;10.Service de neurochirurgie pédiatrique, H?pital Necker-Enfants malades, Université Paris Descartes, Sorbonne Paris Cité,Paris,France;11.Service d’onco-hématologie pédiatrique, H?pital Pellegrin Tripode,Bordeaux,France |
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| Abstract: | PurposeTo investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT.MethodsWe pooled data from two French national population-based case–control studies with similar designs conducted in 2003–2004 and 2010–2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender, were interviewed through telephone, which included questions about prenatal parental smoking and maternal consumption of alcohol, coffee and tea. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex and study of origin.ResultsNo association was seen between CBT and the mother smoking or drinking alcohol, coffee, or tea during the index pregnancy. The OR between CBT and paternal smoking in the year before birth (as reported by the mother) was 1.25 (95% CI 1.03, 1.52) with an OR of 1.09 (0.99, 1.19) for every 10 cigarettes per day (CPD) smoked. The association between paternal smoking and CBT appeared to be stronger in children diagnosed before the age of five years (OR 1.52, 95% CI 1.14, 2.02) and for astrocytoma (OR 1.86, 95% CI 1.26, 2.74).ConclusionWe found some evidence of a weak association between paternal smoking in the year before the child’s birth and CBT, especially astrocytomas. These findings need to be replicated in other samples, using similar classifications of tumour subtypes. |
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