The effect of chronic administration of caffeine on morphine-induced analgesia, tolerance and dependence in mice |
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| Authors: | M K Ahlijanian A E Takemori |
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| Affiliation: | 1. Pain Research Center and Department of Physiology, Zhongshan Medical School of Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou 510080, PR China;2. Department of Anesthesiology, Cancer Center, Sun Yat-Sen University, State Key Laboratory of Oncology in South China, Collaborative, Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, PR China;3. Department of Pathology, The Red Cross Hospital of Yulin, 1 Jinwang Rd, Yulin 537000, PR China;1. Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic;2. Karel English College in Brno, Brno, Czech Republic;1. Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, PO BOX 12211, Giza, Egypt;2. Animal Development and Biotechnology Group, School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK;3. Department of Animal Biosystem Sciences, College of Agriculture and Life Sciences Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 305-764, Republic of Korea;4. College of Life Sciences, The University of Inner Mongolia, 1010070, People’s Republic of China;5. Taconic Farms Inc., Five University Place Rensselaer, NY 12144-3439, USA;1. MOE Key Laboratory of Modern Teaching Technology, Center for Teacher Professional Ability Development, Shaanxi Normal University, 113#, No.199, South Chang’an Road, Xi''an, Shaanxi province, 710062, China;2. Department of Plastic Surgery, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China;3. Department of Neurology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China |
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| Abstract: | Morphine-induced analgesia, and the development of morphine-induced tolerance and dependence was determined in mice which had drunk caffeinated water (1 mg/ml) for 14 days or in mice which had received (-)-N6-(phenylisopropyl)-adenosine (PIA) 1 mg/kg i.p. for 14 days. Analgesia was assessed by the tail flick assay. The development of dependence was assessed by determining the ED50 of naloxone to precipitate withdrawal jumping (3 h after 100 mg/kg morphine pretreatment or 72 h after s.c. implantation of a morphine 75 mg pellet) and by determining the extent of naloxone-precipitated hypothermia in morphine-implanted animals. In mice chronically administered caffeine, the ED50 for morphine-induced analgesia was significantly decreased while the naloxone ED50 for withdrawal jumping increased by 2-fold after both types of morphine pretreatment. In control animals (tap water for 14 days), doses of 1 and 10 mg/kg of naloxone caused significant hypothermia in morphine-implanted animals. Doses of naloxone up to 100 mg/kg did not cause significant hypothermia in morphine-implanted animals which had received chronic caffeine. The development of tolerance was determined by computing the morphine potency ratio for the tail flick assay (tolerant ED50/control ED50). In mice chronically administered caffeine, the potency ratio was decreased significantly in morphine-implanted animals when compared to control. Morphine-induced analgesia, tolerance and dependence was not changed significantly in animals chronically administered PIA. Neither the distribution of morphine to the brain nor the opioid receptor binding parameters for [3H]etorphine and [3H]naltrexone were altered in mice chronically administered caffeine or PIA.(ABSTRACT TRUNCATED AT 250 WORDS) |
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