Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based survey |
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| Authors: | Elin Hestvik James K Tumwine Thorkild Tylleskar Lena Grahnquist Grace Ndeezi Deogratias H Kaddu-Mulindwa Lage Aksnes and Edda Olafsdottir |
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| Institution: | (1) Centre for International Health, University of Bergen, ?rstadveien 21, N-5009 Bergen, Norway;(2) Department of Paediatrics, Haukeland University Hospital, N-5021 Bergen, Norway;(3) Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, P.O Box 7072, Kampala, Uganda;(4) Department of Women’s and Children’s Health, Karolinska Institutet, 17176 Stockholm, Sweden;(5) Department of Microbiology, School of Medicine, School of Biomedical Sciences, Makerere University College of Health Sciences, P.O Box 7072, Kampala, Uganda;(6) Department of Clinical Medicine, University of Bergen, Bergen, Norway |
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| Abstract: | Background Calprotectin is a calcium and zinc binding protein, abundant in neutrophils and is extremely stable in faeces. Faecal calprotectin
is used as a non-specific marker for gastrointestinal inflammation. It has a good diagnostic precision to distinguish between
irritable bowel syndrome and inflammatory bowel disease. Studies have established normal concentrations in healthy children;
all these studies have been performed in high-income countries. The objective of this study was to determine the concentration
of faecal calprotectin in apparently healthy children aged 0-12 years in urban Kampala, Uganda. |
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