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Cyto‐histological correlation of Xp11.2 translocation/TFE3 gene fusion associated renal cell carcinoma: Report of a case with review of literature
Authors:Varsha Manucha MD  Mary T Sessums MD  Jack Lewin MD  Israh Akhtar MD
Institution:Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi
Abstract:The MiT family translocation renal cell carcinomas (RCCs) are relatively rare in comparison to the conventional RCC. The cytologic features overlap with conventional clear cell RCC and papillary RCCs, thereby making the diagnosis extremely challenging. Here, we describe a case of TFE3 translocation associated RCC in a 58‐year‐old patient, with emphasis on cytomorphologic features and clues toward this diagnostic entity. Correlating the cytohistologic findings and review of touch imprints revealed that presence of hyaline nodules resembling leisegang rings and psammoma bodies in cytologic smears from kidney tumors serve as an important clue in raising a suspicion for the diagnosis of MiT family translocation RCCs.
Keywords:cytology  MiT family translocation renal cell carcinomas  t(6  11) renal cell carcinoma  Xp11 translocation renal cell carcinoma
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