Assessment of the antinociceptive and ulcerogenic activity of the tapentadol–diclofenac combination in rodents |
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| Authors: | Juan R. Zapata‐Morales Ángel J. Alonso‐Castro Vinicio Granados‐Soto Sergio Sánchez‐Enriquez Mario A. Isiordia‐Espinoza |
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| Affiliation: | 1. Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México;2. Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados (Cinvestav), sede Sur, Ciudad de, México, México;3. Departamento de Clínicas, División de Ciencias Biomédicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México |
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| Abstract: | | Preclinical Research & Development | The objective of the present study was to evaluate the tapentadol–diclofenac combination in three dose‐ratios in the mouse acetic acid‐induced visceral pain and their ulcerogenic activity on the stomachal mucous. Dose‐response curves were generated for tapentadol, diclofenac, and their combination in the acetic acid‐induced writhing test in mice. Moreover, the stomachs of animals were surgically removal and gastrointestinal ulcerogenic action of the combination was assessed. The isobolographic analysis, interaction index, and ANOVA were used to analyze the data. The isobolographic analysis and interaction index showed a similar antinociceptive activity for the three combinations of the analgesic mixture. Moreover, tapentadol and the proportions 1:1 or 3:1 of the analgesic combination caused a mild gastrointestinal damage. These data indicate that the systemic co‐administration of tapentadol and diclofenac produced a synergistic interaction in the acetic acid‐induced visceral pain test with an acceptable gastric damage profile in mice. |
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| Keywords: | acetic acid‐induced writhing test antinociceptive synergistic interaction diclofenac gastrointestinal damage tapentadol |
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