肿瘤标志物CEA、NSE、CYFRA21-1在胸腔积液鉴别诊断中的应用价值

目的探讨胸腔积液中肿瘤标志物癌胚抗原（CEA）、细胞角蛋白19片断（CYFRA21-1）、神经元特异性烯醇化酶（NSE）检测在胸腔积液鉴别诊断中的价值。方法应用电化学发光法对65例肺癌患者和28例良性对照者的血清和胸腔积液进行检测。结果肺癌组血清和胸水三项肿瘤标志物水平明显高于良性对照组（P〈0．01）；肺癌组胸水三项指标水平高于血清（P〈0．01）；CEA对肺腺癌，NSE对小细胞肺癌，CYFRA21—1对肺鳞癌的阳性率高于其他单项（P〈0．05）。结论胸腔积液CEA、NSE、CYFRA21—1检测有助于肺癌的诊断。

Value of Tumor Markers CEA,NSE and CYFRA21-1 in Differential Diagnosis of Pleural Effusion

Objective To investigate the value of the detection of tumor markers careinoembryonic antigen（CEA）, eytokeratin 19 fragment （CYFRA21-1）and neuron-specific enolase（NSE）in the differential diagnosis of pleural effusion. Methods The serum and pleural effusion in 65 cases of lung cancer and 28 benign controls were detected by electrochemical luminescence. Results The levels of the three tumor markers in serum and pleural effusion of lung cancer group were signifieantly higher than those in serum and pleural effusion of benign control group （P〈0.01）,the levels of three indicators in pleural effusion were higher than those in serum（P〈0.01 ） and the positive rates of CEA in lung adenoearcinoma,NSE in small cell lung cancer and CYFRA21-1 and in lung squamous cell carcinoma were higher than the rate of any other single une（P〈0.05）. Conclusion The detection of pleural effusion CEA, NSE and CYFRA21-1 is helpful in the diagnosis of lung cancer.