| 涎腺良恶性多形性腺瘤中癌基因C—myc表达的斑点杂交研究 |
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| 引用本文： | 王洁,董福生.涎腺良恶性多形性腺瘤中癌基因C—myc表达的斑点杂交研究[J].现代口腔医学杂志,1999,13(3):176-178. |
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| 作者姓名： | 王洁 董福生 |
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| 作者单位： | 河北医科大学口腔医学院 |
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| 基金项目： | 卫生部优秀青年科技人才专项科研基金 |
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| 摘 要： | 目的 探讨癌基因Ｃ－ｍｙｃ的改变与良恶性多形性腺瘤发生的关系。方法 采用斑点杂交研究４２例涎腺良恶性多形性腺瘤中Ｃ－ｍｙｃ癌基因的表达。结果 涎腺多形性腺瘤中Ｃ－ｍｙｃ癌基因表达均值高于正常腮腺组织（Ｐ〈０．０５）。结论 在涎腺良恶性多形性腺瘤的发生过程中，Ｃ－ｍｙｃ癌基因有激活和过量表达。
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| 关 键 词： | 斑点杂交 C－myc 癌基因 多形性腺瘤 涎腺肿瘤 |
Blotting Study of DNA expression of C myc oncogene in pleomorphic adenoma of salivary gland |
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| Wang Jie,Dong Fusheng,Yong Ping,et al..Blotting Study of DNA expression of C myc oncogene in pleomorphic adenoma of salivary gland[J].Journal of Modern Stomatology,1999,13(3):176-178. |
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| Authors: | Wang Jie Dong Fusheng Yong Ping |
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| Institution: | Wang Jie,Dong Fusheng,Yong Ping,et al. Shool of Stomatology,Hebei Medical University Shijiazhuang,050017. |
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| Abstract: | In this study, C myc DNA levels in 42 tissue samples of patients with benign and malignant pleomorphic adenoma were detected by blotting method. The results showed that the expression levels of C myc DNA in both benign and malignant pleomorphic adenomas were higher than that in normal parotid tissue (P<0.05, respectively). No significance of C myc DNA expression levels was found between benign and malignant pleomorphic adenomas(P>0.05) It is suggested that C myc oncogene was activated and overexpressed in tumorigenesis of both benign and malignant pleomorphic adenoma. |
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| Keywords: | C myc Oncogene Pleomorphic adenoma Sorthern blot Salivary gland |
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