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| 氨基胍对STZ糖尿病大鼠视网膜毛细血管超微结构的影响 | |
| 引用本文： | 庞东渤,刘学政,李艳芹,刘玉玲,杨光,吕品.氨基胍对STZ糖尿病大鼠视网膜毛细血管超微结构的影响[J].辽宁医学院学报,2003,24(3):8-10. |
| 作者姓名： | 庞东渤 刘学政 李艳芹 刘玉玲 杨光 吕品 |
| 作者单位： | 1. 锦州医学院解剖学教研室,辽宁,锦州,121001 2. 锦州医学院电镜室,辽宁,锦州,121001 3. 辽河油田中心中心医院,辽宁,盘锦,12400 |
| 基金项目： | 辽宁省自然科学基金资助项目 (编号 0 0 2 114 ) |
| 摘 要： | 目的观察病程6月STZ糖尿病大鼠视网膜毛细血管超微结构的病理改变及氨基胍对超微结构改变的影响。方法制备STZ糖尿病大鼠动物模型，随机分为正常对照(CON)组、糖尿病(13M)组及氨基胍(AG)组。每组大鼠各8只，饲养6个月时处死，取大鼠视网膜进行电镜观察。结果DM组视网膜周细胞、内皮细胞核染色质浓缩，边集，分布于核膜下；胞质内线粒体肿胀，变性，空泡化，胞浆消失；基底膜增厚。结论氨基胍对STZ糖尿病大鼠视网膜毛细血管超微结构的损害有明显防治作用。 |
| 关 键 词： | 氨基胍 糖尿病视网膜病变 毛细血管 超微结构 大鼠 |
| 文章编号： | 1000-5161(2003)03-0008-03 |
Influence of Aminoguanidine on Retinal Capillary Ultrastructure in Diabetic Rats |
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| PANG Dong-bo ,LIU Xue-zheng ,LI Yan-qin ,LIU Yu-ling ,YANG Guang,LU Pin.Influence of Aminoguanidine on Retinal Capillary Ultrastructure in Diabetic Rats[J].Journal of Liaoning Medical University (LNMU) Bimonthly,2003,24(3):8-10. | |
| Authors: | PANG Dong-bo LIU Xue-zheng LI Yan-qin LIU Yu-ling YANG Guang LU Pin |
| Institution: | PANG Dong-bo 1,LIU Xue-zheng 1,LI Yan-qin 2,LIU Yu-ling 2,YANG Guang,LU Pin 3 |
| Abstract: | Objective To observe the pathogenic changes of retinal capillary ultrastructure in diabetic rats and structure changes of aminoguanidine. Methods Animal models were induced by streptozocin and randomly divided into diabetic mellitus(DM) group aminoguanidine(AG)group and control group.The rats were killed at 6 months and their retinas were studied by electronic microscope. Results Ultrastructure of retinal capillary endothelial cells and pericyte were abnormal and it was more obvious in DM group than in AG group. Conclusions Aminoguanidine can effectively provent and cure the damages of retinal capillary ultrastructure in STZ-diabetic rats. |
| Keywords: | diabetic retinopathy capillary ultrastructure aminoguanidine rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |