十二指肠乳头旁憩室与急性胰腺炎的关系

目的 探讨十二指肠乳头旁憩室发生的原因及其与急性胰腺炎的关系.方法 回顾性分析内镜逆行胆胰管造影术(endoscopic retrograde cholangiopancreatography,ERCP)检查患者540例,记录检查指征及诊断.分析十二指肠乳头旁憩室(juxta-papilary duodenal diverticulum,JPD)的发生与年龄的关系；比较胰腺炎与非胰腺炎合并JPD的差异.结果 JPD发生率为23.15％；JPD组平均年龄显著高于非憩室组(t=4.53,P＜0.0001)；高龄(≥61岁)患者JPD发生率显著高于低龄(≤60岁)患者(P＜0.05)；排除胆总管结石,以急性胰腺炎为ERCP检查指征患者JPD发生率为24％(20/84),显著高于非胰腺炎组JPD发生率9％ (39/456)(P=0.0001).结论 JPD更常见于高龄患者,其发生与年龄相关；JPD的存在与急性胰腺炎的发病密切相关,是急性胰腺炎发作的重要因素.

Relationship between juxta-papilary duodenal diverticulum and acute pancreatitis

Objective To investigate the relationship between juxta-papilary duodenal diverticulum(JPD) and acute pancreatitis(AP).Methods Five hundred and forty patients underwent endoscopic retrograde cholangiopancreatography(ERCP).The correlation of JPD with age and acute pancreatitis was analyzed.Results The JPD was detected by ERCP in 125 patients with a prevalence rate of 23.2%.The average age of JPD group was significantly higher than that of non-JPD group(t=4.53,P<0.0001).Significant difference was observed in detection rate of JPD between patients ≥61y and those ≤60y.Excluded the cases who complicated with common bile duct stones,the detection rate of JPD in AP group(23.8%,20/84) was significantly higher than that(8.6%,39/456) in non-AP group(P=0.0001).Conclusion JPD occurs more often in elderly patients,and closely correlated with AP,indicating that JPD might be a risk factor for AP.