| 脑缺血-再灌注动物模型的改良与评价 |
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| 引用本文： | 杨德兵,马存根,尉杰忠. 脑缺血-再灌注动物模型的改良与评价[J]. 中国医药指南, 2011, 9(14): 6-7 |
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| 作者姓名： | 杨德兵 马存根 尉杰忠 |
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| 作者单位： | 山西大同大学脑科学研究所,山西,大同,037009 |
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| 基金项目： | 山西省优秀教学团队《脑科学系列课程教学团队》和山西大同大学博士科研启动经费 (项目 |
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| 摘 要： | 目的对大鼠脑缺血-再灌注模型的制备方法进行改进,使得成功率更高、操作更为简便。方法将传统的自颈外动脉插线转入颈内动脉改为由颈总动脉插线直接进入颈内动脉制备大鼠大脑中动脉缺血-再灌注模型,并进行大鼠行为学的评价,以观察改良方法的可靠性。结果改良组大鼠出现神经功能障碍,脑组织缺血梗死,较对照组操作简单,缺血成功率高。结论该改良法制备的模型是研究局灶性脑缺血的更为理想的实验动物模型。
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| 关 键 词： | 脑缺血-再灌注 动物模型 行为评价 大脑中动脉 |
Improvement and Evaluation of Animal Model of Cerebral Ischemia |
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| YANG De-bing,MA Cun-gen,WEI Jie-zhong. Improvement and Evaluation of Animal Model of Cerebral Ischemia[J]. Guide of China Medicine, 2011, 9(14): 6-7 |
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| Authors: | YANG De-bing MA Cun-gen WEI Jie-zhong |
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| Affiliation: | YANG De-bing,MA Cun-gen,WEI Jie-zhong(Institute of Brain Science,Datong University,Datong 037009,China) |
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| Abstract: | Objective To improve the preparation method of rat cerebral ischemia and reperfusion model,making the success rate higher and the operation more convenient.Methods To change the traditional method,insert the fishing line from the cable directly into the rat carotid artery and further middle cerebral artery,the ischemia-reperfusion model was made.The rats' behavior was evaluated in order to observe the improved reliability of the method.Results There are less neurological dysfunctions in the modified group i... |
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| Keywords: | Cerebral ischemia Animal model Behavior evaluation Middle cerebral artery |
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