长效奥曲肽治疗垂体促甲状腺激素瘤一例临床探讨

一例56岁男性垂体促甲状腺激素（TSH）瘤患者,病史一年,有心悸、怕热、多汗等高代谢症候群;甲状腺肿大;在血甲状腺激素水平明显增加的同时,TSH水平升高;核磁扫描示垂体肿瘤.经长效奥曲肽20mg注射一次治疗后,肿瘤体积缩小,甲状腺功能明显好转,治疗后第28天转为正常.长效奥曲肽可为TSH瘤患者手术前的常规用药,有利于手术顺利进行及术后康复.

A case of thyrotropin-secreting pituitary adenoma treated with long-acting octreotide formulation

A 56-year-old man with 1-year history of palpitation, heat intolerance and sweating, was diagnosed as thyrotropin (TSH) -secreting pituitary adenoma based on the symptoms of hypermetabolism, enlarged thyroid gland, inappropriately increased serum TSH concomitantly elevated plasma thyroid hormones and a pituitary tumor demonstrated on magnetic resonance imaging. Long-acting octreotide formulation was administered at a dose of 20 mg intramuscularly. Tumor volume shrinkage and improvement of thyroid function was achieved after a single drug injection; and the thyroid function returned to normal in 28 days. It is suggested that long-acting octreotide formulation might be used as a routine therapeutic approach prior to pituitary surgery, which may enhance the effectiveness of surgery and postoperative recovery.