神经营养因子参与帕金森病的发生及治疗中的潜在作用

日益增多的证据证明 ,神经营养因子能促进神经细胞生长、增殖 ,延长生存时间 ,并参与帕金森病等神经退行性疾病的发病与病理进程。本文就神经营养因子参与帕金森病的发病及对帕金森病治疗的潜在可能性作一介绍。1　神经胶质细胞来源的神经营养因子与帕金森病　　神经胶质细胞来源的神经营养因子 (ｇｌｉａｌｃｅｌｌｌｉｎｅ -ｄｅｒｉｖｅｄｎｅｕｒｏｔｒｏｐｈｉｃｆａｃｔｏｒ,ＧＤＮＦ)自 1993年发现以来 ,国内外许多研究学者对其药理及生理功能进行了深入细致的研究。已证明ＧＤＮＦ是一个神经胶质细胞分泌的重要的多巴胺能神经元存活…

The potential role of neurotrophic factor in the pathogenesis and therapy of Parkinson''''s disease

Parkinson's disease is characterized by degeneration and dysfunction of dopaminergic neurons in the mid-brain substantia nigra, neurons that project to the caudate putamen. The clinical symptoms are caused by the loss of dopamine and the consequent dysfunction of the nigrostriatal pathway. Neurotrophic factors that may prevent nigrostriatal degeneration by improving the function of remaining dopaminergic neurons has the potential to be a useful therapy for Parkinson's disease. Neurotrophic factors and their specific receptors could play an important role in the progress of Parkinson's disease. The neuroprotective effects of neurotrophic factors GDNF, BDNF, IL-6 on dopaminergic neurons in vivo and in vitro , and the potential therapeutic use in treating Parkinson's disease were discussed in this paper.