Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction. |
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Authors: | Maurizio Ferrario Margherita Massa Vittorio Rosti Rita Campanelli Marco Ferlini Barbara Marinoni Gaetano Maria De Ferrari Valentina Meli Mara De Amici Alessandra Repetto Anna Verri Ezio Bramucci Luigi Tavazzi |
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Affiliation: | Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, P.le Golgi 2, 27100 Pavia, Italy. m.ferrario@smatteo.pv.it |
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Abstract: | AIMS: We studied plasma erythropoietin (EPO) levels and their relation with CD34(+)VEGFR-2(+) (mature and progenitor endothelial cells) and CD34(+) CD133(+)VEGFR-2(+), or CD34(+) CD117(+)VEGFR-2(+) (early/immature endothelial progenitors) cells in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: Fifty AMI patients undergoing percutaneous coronary intervention (PCI) within 6 h of symptom onset were enrolled. EPO, measured by ELISA, and cell subsets, by cytofluorimetric analysis, were evaluated before PCI, 24 h and 7 days afterwards. Forty-five healthy subjects (CTRLs) were studied. Plasma EPO levels were higher in AMI patients at admission, 24 h, and 7 days (P = 0.04, P = 0.0001, P = 0.001, respectively) than in CTRLs. No correlation was evidenced between EPO and haemoglobin (Hb) or haematocrit at admission or 24 h after AMI. Differently, both Hb and haematocrit inversely correlated with EPO at day 7 (P = 0.0016, P = 0.029, respectively). Plasma EPO levels correlated with CD34(+)CD133(+)VEGFR-2(+) cells at day 7 (P = 0.03). CONCLUSION: AMI patients have increased plasma EPO levels until day 7. In the early phase, plasma EPO levels are Hb-independent; at day 7, an Hb-modulated increase of EPO correlates with the percentage of CD34(+)CD133(+)VEGFR-2(+) cells. |
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Keywords: | Acute myocardial infarction Erythropoietin Vascular endothelial growth factor Endothelial progenitors |
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