膀胱小细胞癌诊疗体会:附病例报告

目的探讨膀胱小细胞癌(SCCB)的临床、病理特征及诊疗方法。方法总结2例SCCB患者的临床资料并进行国内外文献复习。结果 2例SCCB患者均为男性。患者1分期T2N0M0,行根治性膀胱切除加化疗,存活。患者2 SCCB含有移行细胞癌成分,分期T4N3M1,接受2个疗程化疗,存活9个月。结论原发性SCCB是罕见的恶性肿瘤,目前没有一个标准的治疗方案,对于早期未发生远处转移的局限性肿瘤,手术+辅助化疗或新辅助化疗可提高患者长期无病生存率和整体存活率;对于已发生远处转移的肿瘤,主要采取以顺铂为基础的化疗方案。

Small Cell Carcinoma of the Urinary Bladder

Objective To evaluate the clinical and pathological characteristics and treatment of small cell carcinoma of the urinary bladder(SCCB).Methods Clinical data of 2 patients with SCCB were summarized and relevant literatures from China and abroad were reviewed.Results Two patients were male.The stage was T2N0M0 in Case 1,who underwent radical cystectomy followed by chemotherapy.The stage was T4N3M1 in Case 2,who had components of and transitional cell carcinoma and received 2 courses of chemotherapy.Case 1 survived and Case 2 died 9 months after chemotherapy.Conclusion Primary SCCB is a rarely seen malignant tumor without standard treatment.For early localized tumor,cystectomy combined with adjuvant chemotherapy or neoadjuvant chemotherapy can improve patients′ disease-free and overall survival.For metastatic tumor,the chemotherapy using platinum agent is the most adopted treatment.