鬼臼毒素酊联合重组人干扰素a-2b凝胶治疗外阴尖锐湿疣临床观察

目的 观察鬼臼毒素酊联合重组人干扰素a-2b凝胶治疗外阴尖锐湿疣的疗效.方法 外阴尖锐湿疣患者126例,其中鬼臼毒素酊联合重组人干扰素a-2b凝胶(A组)66例,对照组60例采用鬼臼毒素酊治疗；两组均在治疗后4、8、16、24周随访.结果 治疗后24周,最终临床治愈率A组为89.4％、B组69％,再次复发率A组10.6％ (7/66),B组31％ (19/60),两组比较有显著性差异,两组出现的不良反应短暂而轻微.结论 鬼臼毒素酊联合重组人干扰素a-2b凝胶治疗外阴尖锐湿疣疗效较好,可明显降低复发率.

Clinical observation of the effect of Podophyllotoxin tincture combined with recombinant human interferon a-2b Gel in the treatment of condyloma acuminatum

Objective Observation of the effect of podophyllotoxin tincture combined with recombinant human interferon a-2b gel in the treatment of condyloma acuminatum of vulva.Methods 126 cases with condyloma acuminatum of vulva,66 cases（group A） with the treatment of podophyllotoxin tincture combined with recombinant human interferon a-2B gel,60 cases（group B） with podophyllotoxin treatment,and than followed up both group at 4,8,12,16,and 24 weeks.Results 24 weeks after treatment,the clinical cure rate was 89.4% in group A,and 69% in group B,there were significant differences（P0.01）.Conclusion P odophyllotoxin tincture combined with recombinant human interferon a-2B gel is a better method in the treatment of condyloma acuminatum of vulva conparad with podophyllotoxin tincture only.It can decrease the recurrence of condyloma acuminatum of vulva significantly.