高血压合并颈动脉粥样硬化患者血清C-反应蛋白的水平变化

目的探索高血压合并颅外颈动脉粥样硬化患者血清C-反应蛋白的水平变化。方法对92例高血压患者采用血管外高分辨超声进行检测,以内膜-中层厚度≥1.0 mm或发现动脉斑块为阳性结果并用酶联免疫法检测血清C-反应蛋白水平。结果在92例高血压患者中,共检出颈动脉粥样硬化患者48例,检出率为52.2%,在男性和女性中,颈动脉粥样硬化检出率差异无统计学意义,合并颈动脉粥样硬化的高血压患者血清C-反应蛋白水平为(3.2±2.4)mg/ml],高于无颈动脉粥样硬化并发症的高血压患者(2.1±1.5)mg/ml](P0.05)。结论在高血压病患者中,C-反应蛋白与颈动脉粥样硬化密切相关。

The serum levels of CRP in essential hypertensive patients with extracranial carotid atherosclerosis

Objective To study the serum levels of C-reactive protein(CRP) in essential hypertensive patients with extracranial carotid atherosclerosis.Methods A high-resolution extravascular B-mode ultrasonographic measurement were used in 92 essential hypertensive patients.The carotid atherosclerosis was identified as intimal-medial thickness≥1.0 mm or finding of carotid plaques.Enzyme-linked immunosorbent assay was used to examine the level of serum C-reactive protein.Results Carotid atherosclerosis were identified in 48 participatients.There was no difference in carotid atherosclerosis prevalence between the male and female patients,however,the serum levels of CRP in essential hypertensive patients with extracranial carotid atherosclerosis were higher than those in essential hypertensive patients without extracranial carotid atherosclerosis(2.1±1.5) mg/ml vs(3.2±2.4) mg/ml],(P < 0.05 ).Conclusion The serum levels of CRP in essential hypertensive patients was associated with extracranial carotid atherosclerosis.