首页 | 本学科首页   官方微博 | 高级检索  
检索        

泽兰有效部分对血小板聚集和血栓形成的影响
引用本文:石宏志,高南南,李勇枝,余竞光,范全春,白桂娥.泽兰有效部分对血小板聚集和血栓形成的影响[J].中草药,2003,34(10):923-926.
作者姓名:石宏志  高南南  李勇枝  余竞光  范全春  白桂娥
作者单位:1. 航天医学工程研究所,北京,100094
2. 中国医学科学院,中国协和医科大学药用植物研究所,北京,100094
基金项目:国家自然科学基金资助项目 (39770 899)
摘    要:目的 研究泽兰有效部分L.F04:对血小板聚集和血栓形成的影响,探讨其活血化瘀作用机制。方法用高分子右旋糖酐静脉推注造成大鼠血瘀证模型,观察泽兰L.F04对二磷酸腺苷(ADP)诱导的大鼠体内血小板聚集以及体内动静脉旁路血栓、体外旋转环内血栓形成的影响。结果 L.F04 0.408,0.204g/kg对模型组大鼠ADP诱导的体内血小板最大聚集率明显增加皆有显著的抑制。且呈剂量依赖关系;与对照组相比,血瘀模型大鼠体外血栓质量明显增加,长度仅有增加趋势,L.F04高、低剂量(0.408,0.204g/kg)皆有抗血栓形成作用,L.F04高剂量对血栓干质量、湿质量的减轻尤为明显;L.F04高、低剂量对实验性动静脉旁路血栓形成均有明显的抑制作用,抑制率分别为27.41%,27.14%。结论泽兰L.F04可显著抑制血小板聚集及体内、外血栓形成。

关 键 词:泽兰  血小板聚集  血栓
文章编号:0253-2670(2003)10-0923-04
收稿时间:2002/12/18 0:00:00
修稿时间:2002年12月18

Effects of active fractions L.F04 from ground part of Lycopus lucidus var.hirtus on platelet aggregation and thrombosis formation
SHI Hong zhi,GAO Nan nan,LI Yong zhi,YU Jing guang,FAN Quan chun and BAI Gui e.Effects of active fractions L.F04 from ground part of Lycopus lucidus var.hirtus on platelet aggregation and thrombosis formation[J].Chinese Traditional and Herbal Drugs,2003,34(10):923-926.
Authors:SHI Hong zhi  GAO Nan nan  LI Yong zhi  YU Jing guang  FAN Quan chun and BAI Gui e
Institution:SHI Hong zhi 1,GAO Nan nan 2,LI Yong zhi 1,YU Jing guang 2,FAN Quan chun 1,BAI Gui e 1
Abstract:Object To study the effects of active fraction L.F04 from the ground part of Lycopus lucidus Turcz. var. hirtus Reg. on platelet aggregation and thrombosis formation and investigate its mechanisms of promoting blood circulation and removing blood stasis. Methods The effects of L.F04 on platelet aggregation induced by ADP in vivo, thrombosis of artery vein side road and thrombus formed in rotary loop in vitro were examined, the rat model of blood stasis made by injecting high molecular weight dextran (HMWD) was used. Results L.F04 0.408 and 0.204 g/kg evidently inhibited the ADP induced increase of platelet maximum aggregation rate in vivo in HMWD model, with a concentration dependent manner. Compared with the control group, the thrombus weight in rat model of blood stasis was increased significantly and the length of thrombus was shown an increasing trendency. L.F04 0.408 and 0.204 g/kg both shown the anti thrombosis effect. L.F04 0.408 g/kg showed better effects of lessening the thrombus dry weight and wet weight. Both L.F04 0.408 and 0.204 g/kg could inhibit the thrombosis of artery vein side road, the inhibition rates are separately 27.41% and 27.14%. Conclusion L. lucidus var. hirtus F04 could significantly inhibit platelet aggregation and thrombosis formation.
Keywords:the ground part of Lycopus lucidus var  hirtus Reg    platelet aggregation  thrombosis  
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中草药》浏览原始摘要信息
点击此处可从《中草药》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号