| Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains |
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| 引用本文： | QING HUA ZOU,BO QING LI and JIAN ZHONG ZHANGNational Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,P.R.China. Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains[J]. 中华微生物学和免疫学杂志(英文版), 2005, 3(2): 83-88 |
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| 作者姓名： | QING HUA ZOU BO QING LI and JIAN ZHONG ZHANGNational Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing P.R.China |
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| 作者单位： | QING HUA ZOU，BO QING LI and JIAN ZHONG ZHANGNational Institute for Communicable Disease Control and Prevention，Chinese Center for Disease Control and Prevention，Beijing，P.R.China |
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| 摘 要： | Cholera ,as one of the most severe epidemic dis-eases inthe world,can occurin a short time ,andspread quicklyto a wide region.Until 1992 ,onlyV.choleraeserogroup O1 was recognized as thecause of epidemic cholera . However in October1992 ,a major outbreak of a cholera-like illnesscaused by a newserogroupstrain ofV.choleraee-mergedinIndia and Bangladesh.In contrast to allpreviously reported non-O1 strains , which induceonly sporadic cases of human diarrhea without epi-demic potential ,the new…
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| 关 键 词： | 弧菌 S形霍乱菌 结鱼属 流行病学 生物类型 |
Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains |
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| QING HUA ZOU Bo QINC LI JIAN ZHONG ZHANG. Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains[J]. Chinese Journal of Microbiology and Immunology, 2005, 3(2): 83-88 |
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| Authors: | QING HUA ZOU Bo QINC LI JIAN ZHONG ZHANG |
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| Affiliation: | National Institute for Communicable Disease Control arid Prevention, Chinese Center for Disease Control and Prevention, Beijing, P.R. China |
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| Abstract: | The purposes of this study are to compare the proteome of Vibrio cholerae O139 strains with that of O22, O155 and El Tor biotype epidemic strains, and to identify whether O139 strains have a close relation with the latter. Proteins of two V.cholerae serogroup O139 strains, two El Tor biotype epidemic strains, one O22 strain, and one O155 strain were separated by two-dimensional gel electrophoresis (2-DE); the silver stained 2-DE gels were scanned with digital ImageScanner and analyzed with ImageMaster 2D Elite 3.10 software. Similarities of protein maps between these strains were analyzed. The two O139 strains had 86% proteins in common; the two El Tor biotype epidemic strains showed 84% proteins in common; O139 strains shared 67%, 47% and 45% proteins with El Tor biotype epidemic strains, O22 and O155 strains respectively. Although the proteome of O139 strains have close similarity to that of El Tor biotype epidemic strains, great disparities exist. O139 strains may not originate from El Tor biotype directly, and a transition strain may exist. |
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| Keywords: | Vibrio cholerae Two-dimensional gel electrophoresis |
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