| Fribrinolysis Kinetics and Its Application |
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| 作者姓名： | 魏文宁 杨锐 郭涛 杨滔 胡豫 |
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| 作者单位： | Institution of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Institution of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Institution of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Institution of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Institution of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China |
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| 摘 要： | A new, convenient, and rapid method for kinetic measurement of human fibrinolysis was established. The alteration of absorbance (A) in the process of blood coagulation and lyses was auto-matically scanned and recorded using a UV2000 spectrophotometer connected to a computer. The parameters of human fibrinolysis kinetics were established. Urokinase at 20 U/mL was the optimal concentration used. There was significant difference in fibrinolysis kinetics and plasma plasminogen concentration between 22 normal subjects and 27 patients with acute myeloblastic leukemia (P<0.05 and <0.01 respectively). The coefficience of variation was (5.24±1.51)%. This method could also be used to measure the plasma fibrinogen concentration at the same time. It was concluded that this method was stable and was capable of providing dynamic, direct experimental data and multipareme-ters for clinicians. It was also valuable in evaluating the anti- and pro-fibrinolytic capcity of patients' plasmas, allowing for monitoring of therapy, choice of drugs and adjustment of drug concentrations.
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| 关 键 词： | 药物治疗 临床医师 临床监视 血纤维蛋白肽 |
| 收稿时间： | 2005-08-29 |
Fribrinolysis kinetics and its application |
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| Wei Wenning,Yang Rui,Guo Tao,Yang Yan,Hu Yu.Fribrinolysis Kinetics and Its Application[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2007,27(1):111-113. |
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| Authors: | Wei Wenning Yang Rui Guo Tao Yang Yan Hu Yu |
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| Institution: | Institution of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Summary A new, convenient, and rapid method for kinetic measurement of human fibrinolysis was established. The alteration of absorbance
(A) in the process of blood coagulation and lyses was automatically scanned and recorded using a UV2000 spectrophotometer connected
to a computer. The parameters of human fibrinolysis kinetics were established. Urokinase at 20 U/mL was the optimal concentration
used. There was significant difference in fibrinolysis kinetics and plasma plasminogen concentration between 22 normal subjects
and 27 patients with acute myeloblastic leukemia (P<0.05 and <0.01 respectively). The coefficience of variation was (5.24±1.51)%. This method could also be used to measure the
plasma fibrinogen concentration at the same time. It was concluded that this method was stable and was capable of providing
dynamic, direct experimental data and multiparemeters for clinicians. It was also valuable in evaluating the anti-and pro-fibrinolytic
capcity of patients’ plasmas, allowing for monitoring of therapy, choice of drugs and adjustment of drug concentrations.
WEI Wenning, male, born in 1950, Chief Technician |
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| Keywords: | fibrinolysis kinetic measurement prothrombotic state |
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