Adaptive reaction of nigral neurons following lesion of their ventromedial-thalamic projection field |
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Authors: | Helen E. Savaki Jean-Antoine Girault Marcel Desban Jacques Glowinski Marie-Jo Besson |
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Affiliation: | Chaire de Neuropharmacologie, INSERM U 114, Colle´ge de France, 11, Place Marcelin Berthelot, 75231 Paris , Cedex 05France |
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Abstract: | The response of reticulata-nigral neurons to injury of their ventromedial-thalamic (VM) projection was studied in the rat, by the autoradiographic [14C]deoxyglucose method. Electrolytic lesion of the VM induced reversible: reticulata hypoexcitability; and hyporesponsiveness of areas receiving reticulata efferents, to nigral electrical stimulus. The results suggest that distal axonal injury (in the VM) induces reversible rearrangement of functional properties in the nigral parent cells and their uninjured collaterals, as a retrograde reaction. |
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Keywords: | retrograde reaction ventromedial thalamic lesions substantia nigra stimulation |
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