幕上原始神经外胚叶肿瘤的临床病理分析

目的探讨幕上神经外胚叶肿瘤的临床特点、影像学和病理组织学特征,以提高其诊断准确率。方法对我院2003年1月—2007年12月收治的6例幕上神经外胚叶肿瘤的临床资料进行回顾性分析。结果肿瘤位于颞叶、枕叶生长各2例,额叶、侧脑室旁各1例,CT显示为稍高密度影,增强后呈不均一强化。MRI为长T1长T2信号,增强后可强化。肿瘤周围水肿明显。病理检查示瘤细胞体积小,胞浆少,多呈裸核状,纤维芯菊形团结构常见。结论SPNET好发于小儿中枢神经系统,其影像学和组织学表现有一定的特征性,影像学及临床表现相结合有助于术前与其他肿瘤鉴别,提高诊断准确性。

Clinicopathologic Analysis of Supratentorial Primitive Neuroectodermal Tumors

Objective To explore the clinical features,imaging presentations and histopathologic features of supratentorial primitive neuroectodermal tumor(SPNET) for increasing the accuracy rate of diagnosis.Methods The clinical data of 6 patients with SPNET which were confirmed by histological examination and immunohistochemistry were retrospectively reviewed.Results The tumors were located in temporal lobe,occipital area,frontal lobe,area adjacent to lateral ventricle.Tumors were moderate hyperintense on CT.Postcontrast CT showed a inhomogenous enhancement in the mass.On MRI imaging,the tumors is showed as heterogeneous signal intensity in both T1-and T2-weighted images.Peritumoral edema is distint.The histopathologic features showed small cell size and high nucleolus/cytoplasm ratio.The structure of Homer-Wright rosette was commonly seen.Conclusion SPNET generally occur in children's central nervous system.There are some characteristics on imaging and pathology of SPNET.It's helpful to differentiate SPNET from other tumors before operation by combining the imagines with clinical manifestation.This can increase the accuracy rate of diagnosis.