子宫动脉灌注栓塞化疗与静脉化疗治疗宫颈癌患者的毒副作用与近期疗效观察

目的 探讨子宫动脉灌注栓塞化疗与静脉化疗对于宫颈癌患者的毒副作用与近期疗效情况.方法 选取2013年1月至2014年1月期间在本院进行化疗的宫颈癌患者110例,根据电脑抽签方法随机分成两组,其中对照组55例给予静脉化疗,观察组55例给予子宫动脉灌注栓塞化疗,比较两组患者近期疗效.结果 观察组总有效率(80.00％)显著高于对照组(56.36％);观察组病理有效率(76.36％)显著高于对照组(52.73％),观察组淋巴转移率、宫颈旁浸润率、阴道切缘阳性率、脉管转移率均显著低于对照组;两组患者白细胞减少Ⅰ、Ⅱ级,神经毒性Ⅰ、Ⅱ级发生率,以及各类型不良反应方面Ⅲ、Ⅳ级发生率比较差异无统计学意义(P＞0.05);观察组胃肠道反应Ⅰ、Ⅱ级,脱发Ⅰ、Ⅱ级发生率显著低于对照组(P＜0.05);两组患者术后一年全部存活,无死亡.结论 给予宫颈癌患者进行子宫动脉灌注栓塞化疗治疗可显著提高化疗有效率,对于有效改善病理情况、降低化疗不良反应具有积极意义.

Toxic and side effect and short-term curative effect of uterine arterial chemoembolization and intravenous chemotherapy in cervical cancer

Objective To investigate toxic and side effect and short-term curative effect of uterine arterial chemoembolization and intravenous chemotherapy in cervical cancer.Methods 110 cases of cervical cancer who underwent chemotherapy in our hospital from January 2013 to January 2014 were selected,and randomly divided into two groups according to the computer balloting.55 cases in control group received intravenous chemotherapy,while 55 cases in observation group received uterine arterial chemoembolization.Compared short-term curative effect of two groups.Results The total effective rate of observation group was 80％,significantly higher than 56.36％ of control group;the efficiency of pathology of observation group was 76.36％,significantly higher than 52.73％ of control group.The rates of lymph node metastasis,paracervical infiltration,vaginal positive margin,vascular metastasis of observation group were significantly lower than those of control group.There were no statistically significant differences in the incidences of leukocytopenia Ⅰ,Ⅱ grade,neurotoxicity Ⅰ,Ⅱ grade,and other types of adverse responses Ⅲ,Ⅳ grade (P＞0.05);the incidences of gastrointestinal reaction Ⅰ,Ⅱ grade,alopecia Ⅰ,Ⅱ grade of observation group were significantly lower than those of control group.Patients of two groups were alive within 1 year,without death.Conclusion Uterine arterial chemoembolization in cervical cancer patients can significantly improve efficiency,has a positive meaning in improving the pathological conditions,reducing adverse effect of chemotherapy.