结核性脑膜炎患者应用脑脊液置换联合鞘内注药的临床疗效研究

目的 探讨脑脊液置换联合鞘内注药对结核性脑膜炎的临床疗效.方法 选择本院2013年2月至2015年1月收治的91例结核性脑膜炎患者作为研究对象,按照随机数字表分为两组:对照组45例采用常规抗结核治疗,而观察组46例则在常规治疗基础上应用脑脊液置换联合鞘内注射药物进行治疗.比较两组临床疗效,并观察不良反应发生情况.结果 治疗后,观察组总有效率为95.7％,明显高于对照组,差异有统计学意义(P＜0.05);观察组脑脊液指标、症状缓解时间等均优于对照组,组间差异具有统计学意义(P＜0.05);两组均未见明显不良反应.结论 脑脊液置换联合鞘内注射药物能够促进患者的脑脊液指标的恢复,提高治疗效率,有效改善结核性脑膜炎患者预后,值得临床应用.

Cerebrospinal fluid replacement combined with intrathecal drug injection for patients with tuberculous meningitis

Objective To evaluate the clinical efficacy of cerebrospinal fluid replacement combined with intrathecal drug injection for patients with tuberculous meningitis.Methods 91 patients with tuberculous meningitis were selected as study objects and randomly divided into a control group (n=45),treated with conventional anti-TB treatment,and an observation group (n=46),treated with cerebrospinal fluid replacement and intrathecal drug injection.The clinical efficacies were compared between these two groups.Results After the treatment,the total efficacy was 95.7％ in the observation group,which was significantly higher than that in the control group,with a statistical difference (P＜0.05).The indicators of cerebrospinal fluid and symptomrelief time were better in the observation group than in the control group,with statistical differences(P＜0.05).No significant adverse reactions occurred in both groups.Conclusions Cerebrospinal fluid replacement combined with intrathecal drug injection for patients with tuberculous meningitis can promote the recovery of their cerebrospinal fluid indicators and effectively improve their prognosis and is worth for clinical application.