Hemorrhagic colitis due to a novel Escherichia coli serotype (O121:H19) in a transplant patient |
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| Authors: | Kent J. Stock Margie A. Scott Stacy F. Davis Richard N. Pierson III J. Stephen Dummer |
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| Affiliation: | (1) Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37 232 USA, US;(2) Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37 232 USA, US;(3) Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37 232 USA, US;(4) The Transplant Center, Vanderbilt University Medical Center, 911 Oxford House, Nashville, TN 37232, USA e-mail: stephen.dummer@mcmail. vanderbilt.edu Tel.: + 1-6 15-9 36 06 81 Fax: + 1-6 15-9 36 19 70, US;(5) Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37 232 USA, US |
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| Abstract: | Infection due to enterohemorrhagic Escherichia coli (EHEC) has not been described in immunosuppressed patients. We recently saw a case of EHEC infection caused by a novel Shiga toxin II-producing Escherichia coli serotype (O121:H19) that caused hemorrhagic colitis in a patient with renal and cardiac transplants. The patient's signs, symptoms, and colon pathology were similar to reports of EHEC infection in immunocompetent patients. This case suggests that the immunosuppressed state may not alter the clinical presentation or histopathologic findings of this disorder. Assays for EHEC are not routinely done at most hospitals. Therefore, clinicians caring for transplant patients should be aware of the typical clinical presentation of EHEC infection, so that they can initiate appropriate laboratory investigation in suspected cases. Received: 27 December 1999 Accepted: 13 September 2000 |
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| Keywords: | Enterohemorrhagic Escherichia coli (EHEC) Kidney transplantation Heart transplantation Colitis Hemolytic-uremic syndrome |
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