| 塞来昔布对人结肠癌细胞VEGF-C表达的影响 |
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| 引用本文： | 李焱,张涛,高辉,魏东,程朋.塞来昔布对人结肠癌细胞VEGF-C表达的影响[J].肿瘤学杂志,2010,16(2):87-89. |
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| 作者姓名： | 李焱 张涛 高辉 魏东 程朋 |
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| 作者单位： | 成都军区总陕院,四川,成都610083 |
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| 摘 要： | 目的]探讨塞来昔布对体外培养的结肠癌细胞血管生长因子C（VEGF-C）表达的影响。方法]以人结肠癌细胞HT29为研究对象,以不同浓度的塞来昔布（0、25、50、100μmol/L）进行处理。采用RT-PCR等方法检测四组细胞中VEGF-C的表达情况。结果]塞来昔布可抑制人结肠癌HT29细胞VEGF-C的表达,抑制作用与塞来昔布的浓度相关。结论]塞来昔布可能通过对肿瘤细胞中VEGF-C基因表达的抑制发挥其抗肿瘤作用。
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| 关 键 词： | 塞来昔布 血管内皮生长因子C 淋巴道转移 结肠肿瘤 |
Effect of Celecoxib on VEGF-C Expression in Colon Cancer Cell Line |
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| LI Yan,ZHANG Tao,GAO Hui,et al..Effect of Celecoxib on VEGF-C Expression in Colon Cancer Cell Line[J].Journal of Oncology,2010,16(2):87-89. |
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| Authors: | LI Yan ZHANG Tao GAO Hui |
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| Institution: | LI Yan,ZHANG Tao,GAO Hui,et al.(General Hospital of Chengdu Military Region,Chengdu 610083,China) |
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| Abstract: | Purpose] To investigate the effect of celecoxib on VEGF-C expression in human colon cancer cell.Methods] The colon cancer HT29 cells were treated with celecoxib at different concentrations 0μmol/L,25μmol/L,50μmol/L,100μmol/L.The expression of VEGF-C was detected by RT-PCR etc.Results] Celecoxib could inhibit expression of VEGF-C in colon cancer cell HT29.The inhibition effect was correlated with the concentration of celecoxib.Conclusion] Celecoxib might play antitumor role by inhibiting the expression of VEGF-C in colon cancer. |
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| Keywords: | celecoxib VEGF-C lymphatic metastasis colon neoplasms |
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