大肠癌亲和酶标法检测雌孕激素受体及临床生物学意义

目的探讨雌孕激素受体与结直肠癌病理、临床及生物学行为的关系。方法应用免疫组织化学的亲和酶标法检测５３例结直肠癌的雌激素受体和孕激素受体。结果雌孕激素受体总阳性率为６０％（３２／５３）；女性和男性阳性率分别为７５％（２１／２８）和４４％（１１／２５），差异有显著意义（Ｐ＜０．０５）。管状乳头状腺癌受体阳性率为７０％，高于印戒细胞和粘液腺癌３８％（Ｐ＜０．０５）；ＤｕｋｅｓＢ期受体阳性率为７５％，高于Ｄ期３３％（Ｐ＜０．０５）；淋巴无转移者受体阳性率为８５％，高于有转移者４５％（Ｐ＜０．０５）。肿瘤体积＜５ｃｍ３者受体阳性率为７１％，高于≥５ｃｍ３者３９％（Ｐ＜０．０５）。直肠癌受体阳性率为７１％，高于结肠癌３３％（Ｐ＜０．０５）。高分化癌受体阳性率为７８％，高于低分化癌３５％（Ｐ＜０．０５）。结论女性大肠癌发病与受体关系密切；受体作用失常参与大肠癌发病始于较早期阶段；直肠癌发病与受体密度增高关系更为密切。

INVESTIGATION ON RECEPTORS IN HUMAN COLORECTAL CARCINOMA AND ITS RELATIONSHIP TO CLINICAL BEHAVIOR

PURPOSE To investigate the relationship of estrogen and progesterone receptors to the pathology,clinical and biological behavior of colorectal carcinoma.METHODS The E2-HRP,Pg-HRP method was used to detect the presence of ER and PR.RESULTS ER positive rate was 60% (32/53),the female and male positive rates were respectively 75% (21/28 ) and 44% (11/25 ), the difference Was significant (P < 0. 05 ). In tubular papilloadenocarcinoma,the receptor positive rate was 70%,higher than the 38% of the signet ring and mucoid adenocarcinomas (P<0. 05). Staging: Dukes' B had a receptor positive rate of 75 %,higher than the 33% of the D cases (P<0. 05);cases without lymph node metastasis had positive rate of 85 %,higher than 45% of the lymph node metastasis negative cases;tumor size less than 5 cm3 was 85%,as compared to the 39 % of the cases with tumors>5 cm3 (P<0. 05). The receptor positive rate for rectal carcinoma was 78 %,higher than the 33% of colon cancer (P<0. 05). High differentiation was 78%,whereas the cases with low differentiation had only 35% (P<0. 05).CONCLUSIONS The occurrence of colon cancer was strongly related to receptors in the female;abnormalities in the function of receptors are factors in the development of colon cancer,especially in the early stages;rectal cancers are even more closely related to the higher concentration of receptors.