补气活血方对高脂饮食大鼠胰岛素分泌的影响

观察补气活血方(黄芪、葛根、川芎等)对高脂高热量饮食大鼠胰岛素分泌的影响。30只正常雄性SD大鼠随机分为正常对照组(A)、高脂喂养组(B)和高脂喂养加中药治疗组(C)，喂养期间观察大鼠体重变化，进行胰岛素耐量试验(ITT)，口服葡萄糖耐量试验(OGTT)和胰岛素释放试验(IRT)。结果：大鼠喂养6个月时，C组体重明显低于B组。C组和A组大鼠血糖下降明显快于B组，C组和A组之间无明显差异。C组大鼠空腹血糖与B组无差异，而在120min时C组血糖显著低于B组，与A组无明显差异。C组0～60min和0～120min胰岛素曲线下面积大于B组，与A组差异不显著。提示：补气活血中药可以降低高脂高热量饮食大鼠体重，增加胰岛素敏感性，促进早期胰岛素分泌，降低葡萄糖负荷后血糖。

The Effect of Qi-Enriching and Blood-Activating Chinese Medicines on Insulin Secretion in High-Fat Diet Feeding Rats

To observe the effect of qi-enriching and blood-activating Chinese medicines on insulin secretion in high-fat diet feeding rats, 30 normal male SD rats were randomized into three groups: group A in which no treatment was given, group B in which high fat diet was fed, and group C in which high-fat diet food and Chinese medicines were given. The changes of rats' body weight during high-fat diet feeding were observed; insulin tolerance test (ITT), oral glucose tolerance test(OGTT) and insulin release test (IRT) were taken to assess the effect of these Chinese medicines on insulin sensitivity and insulin secretion. Results: After 6 months, body weight was significantly lower in group C than in group B (P<0.01); in ITT, blood glucose decreased obviously faster in groups C and than in group B (P<0.05, P<0.01), but no difference between group C and group A; there was no difference in fasting blood glucose between group C and group B; but glucose at 120 minute was significantly lower in group C than in group B (P<0.01); the area under curve of insulin during 0 min- 60 min and 0 min - 120 min was larger in group C than in group B (P<0.05), but no difference between group C and group A. It is indicated that the Chinese medicines could lower the body weight of the rats with high fat and high energy, improve insulin sensitivity, increase insulin secretion and decrease blood glucose after charging glucose.