Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis |
| |
| Authors: | H. I. Brunner E. Ivaskova J. P. Haas A. Andreas E. Keller J. Hoza S. Havelka S. Scholz G. Sierp E. D. Albert |
| |
| Affiliation: | (1) Labor für Immungenetik, Kinderpoliklinik der LMU München, Germany;(2) Institute for Clinical and Experimental Medicine, Charles University, Prague, The Czech Republic;(3) Children's Hospital, Charles University, Prague, The Czech Republic;(4) Institute for Rheumatology, Charles University, Prague, The Czech Republic;(5) Labor für Immungenetik der Kinderpoliklinik München, Pettenkoferstrasse 8 a, W-8000 München 2, Germany |
| |
| Abstract: | Summary A total of 94 patients with juvenile chronic arthritis (JCA) was tested for HLA class I by serology and for class II by RFLP typing. Early onset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males and females. The combination (joint occurrence) of these JCA associated alleles (A2, DR5, DR8) is frequently seen in patients with chronic iridocyclitis. Late onset pauciarticular disease has an increased frequency of HLA-B27, especially in males. Our data confirm that polyarticular JCA with early childhood onset ( 4 years) is associated with DR5 and DR8 and has a different immunogenetic background from polyarticular JCA with later childhood (>4 years) onset (associated with DR4). |
| |
| Keywords: | Juvenile chronic arthritis Early onset Juvenile rheumatoid arthritis HLA-DRB alleles |
| 本文献已被 SpringerLink 等数据库收录！ |
|
