| 冠脑益嗪对豚鼠乳头肌生理特性的影响 |
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| 引用本文： | 陈水英,赵德化,盛宝恒. 冠脑益嗪对豚鼠乳头肌生理特性的影响[J]. 医学争鸣, 1988, 0(6) |
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| 作者姓名： | 陈水英 赵德化 盛宝恒 |
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| 作者单位： | 第四军医大学药理学教研室(陈水英，赵德化)，第四军医大学药理学教研室(盛宝恒) |
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| 摘 要： | 冠脑益嗪(8205)可抑制豚鼠乳头状肌的收缩力,能降低其自律性,延长其不应期,而对兴奋性无明显影响。普诺洛尔和较大剂量的8205,均可使异丙肾上腺素的量-效曲线平行右移,符合竞争性拮抗剂的特点,唯8205的作用远弱于普诺洛尔;维拉帕米与8205,均可使CaCl_2的量-效曲线右移,且其最大收缩幅度,均有明显降低,呈非竞争性拮抗。
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| 关 键 词： | 冠脑益嗪 异丙肾上腺素 普诺洛尔 维拉帕米 氯化钙类 乳头肌 |
Effect of 8205 on Physiological Characteristics of Guinea Pig Papillary Muscles |
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| Chen Shuiying,Zhao Dehua and Sheng Baoheng. Effect of 8205 on Physiological Characteristics of Guinea Pig Papillary Muscles[J]. Negative, 1988, 0(6) |
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| Authors: | Chen Shuiying Zhao Dehua Sheng Baoheng |
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| Affiliation: | Chen Shuiying,Zhao Dehua and Sheng Baoheng Department of Pharmacology |
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| Abstract: | In our experiment it was found that in guinea pig papullary muscles 8205 decreased the automaticity (FRP) and prolonged functional refractory period as well as decreased contractile amplitude dose-dependently, but exerted no effect on the excitability. The dose-response curves of isoproterenol shifted to the right in parallell manner, in accordance with competitive antagonistic, but the effect of 8205 was much less than that of propranolol. Dose-respon se curves of CaC12 shifted to the right non-parallelly. The results indicated that the mechan srn of anti-arrhythmia of 8205 might be related to the Ca-antagonism. |
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| Keywords: | 8205 isoproterenol propranolol verapamil calcium chloride |
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