| 胃癌组织中COX-2蛋白的表达研究 |
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| 引用本文： | 殷新光,杨志宏,王波,王桂华,曹宁珠.胃癌组织中COX-2蛋白的表达研究[J].中国实验诊断学,2005,9(5):711-712. |
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| 作者姓名： | 殷新光 杨志宏 王波 王桂华 曹宁珠 |
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| 作者单位： | 嘉兴市第二医院消化科 浙江嘉兴314000
(殷新光，杨志宏，王波，王桂华)，嘉兴市第二医院消化科 浙江嘉兴314000(曹宁珠) |
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| 摘 要： | 目的探讨胃癌组织中环氧化酶-2(COX-2)表达及其与胃癌浸润转移的关系。方法应用免疫组化S-P法测定57例胃癌组织中COX-2蛋白的表达。结果COX-2在胃癌组织中阳性表达率为85.2%,正常胃粘膜组织中阳性表达率为28.1%,两者有显著性异(P<0.01);COX-2阳性表达与胃癌分化程度无关(P>0.05);与TNM分期、淋巴结转移显著相关(P<0.01)。结论COX-2表达与胃癌的转移、浸润等有关,可作为反映胃癌生物学行为的指标之一。
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| 关 键 词： | 胃癌 COX-2 免疫组化 |
| 文章编号： | 1007-4287(2005)05-0711-02 |
| 收稿时间： | 02 12 2005 12:00AM |
| 修稿时间： | 2005年2月12日 |
The study of cydooxygenase-2 expression in gastric Carcinoma |
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| YIN Xin-Guang, YANG Zhi-hong, WANG Bo,et al..The study of cydooxygenase-2 expression in gastric Carcinoma[J].Chinese Journal of Laboratory Diagnosis,2005,9(5):711-712. |
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| Authors: | YIN Xin-Guang YANG Zhi-hong WANG Bo |
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| Institution: | The Sacond Hospital of Jiaxing City, Zhejiang 314000, China |
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| Abstract: | Objective To explore expression of cyclooxygenase-2(COX-2) and its relationship with invasion and metastasis of gastric carcinoma.Methods The streptavidin-Peroxidase immunohistochemistry was used to determine the expression of cyclooxygenase-2 in 57 tissues of gastric cancer.Results The rates of cyclooxygenase-2 expression in tissues of gastric carcinoma and normal stomach were 85.2% and 28.1%,the level of cyclooxygenase-2 expression had no correlation with histology differentiation of gastric carcinoma(P>0.05).The level of cyclooxygenase-2 expression had significant correlations with lymph node metastasis,deep invaded and TNM stage of gastric carcinoma(P<0.01).Conclusion The level of Cox-2 expression is significantly related to the invasion and metastasis of gastric carcinoma.The level of Cox-2 expression is one of the important biologic character of gastric carcinoma. |
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| Keywords: | gastric carcinoma cyclooxygenase-2 immunohistochemistry |
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