蒙成药阿那日-4对小鼠乙醇及应激反应引起胃溃疡的影响

目的探讨蒙成药阿那日-4对小鼠乙醇及应激反应引起胃溃疡的影响。方法分别建立小鼠乙醇及应激性胃溃疡模型，检测小鼠胃浆中的超氧化物歧化酶（SOD）、丙二醇（MDA）、一氧化氮（NO）含量及比较胃图片溃疡指数来观察蒙成药阿那日-4对两个模型的影响。结果蒙成药阿那日-4对乙醇致胃溃疡小鼠，3个剂量给药组与模型组比较显著增高SOD及NO含量（P〈0．05）、中剂量给药组显著降低MDA含量（P〈0．05），3个剂量给药组的溃疡指数显著降低（P〈0．05），抑制率分别为13．4％，28．1％，59．2％；对应激反应引起的胃溃疡小鼠，与模型组比较，低剂量组SOD含量显著提高（P〈0．01）；中剂量组MDA显著降低（P〈0．05），低、中、高剂量组NO含量显著提高（P〈0．01）、溃疡指数显著降低（P〈0．01），抑制率分别为31．4％，51．0％，44.3％。结论蒙成药阿那日-4对小鼠乙醇及应激反应引起的胃溃疡有一定的治疗作用，这与抗氧化、增高胃浆中的NO含量有关。

Effects of Mongolian Patent Medicine Anari-4 on Gastric Ulcer Induced by Alcohol and Stress Reaction in Mice

OBJECTIVE To investigate the influence of Mongolian patent medicine Anari-4 to gastric ulcer induced by alcohol and stress reaction in mice. METHODS Gastric ulcer models were established by alcohol and stress reaction, respectively. The ulcer index, the contents of superoxide dismutase (SOD), nitric oxide (NO) and malondialdehyde (MDA), pathological sections were measured, respectively. RESULTS Compared with model group, Anari-4 (0.025, 0.05, 0.1 g·kg^-1) significantly increased the contents of SOD and NO in gastric ulcer induced by alcohol (P<0.05). Anari-4 (0.05 g·kg-1) significantly decreased the content of MDA (P<0.05). Anari-4 (0.025, 0.05, 0.1 g·kg^-1) significantly decreased the ulcer index(P<0.05). The inhibitory rates were 13.4%, 28.1% and 59.2%, respectively. Compared with model group, Anari-4 (0.025 g·kg^-1) significantly increased the contents of SOD in gastric ulcer induced by stress reaction (P<0.01). Anari-4 (0.05 g·kg-1) significantly decreased the content of MDA (P<0.05). Anari-4 (0.025, 0.05, 0.1 g·kg^-1) significantly increased the content of NO and decreased the ulcer index(P<0.01). The inhibitory rates were 31.4%, 51.0% and 44.3%, respectively. CONCLUSION Anari-4 plays a protective role against gastric ulcer. Its antiulcer effect is related to inhibiting generation of oxygen derived free radicals, and decreases the content of NO.