Hepatitis e virus infection in fulminant hepatitis patients and an apparently healthy population in Bangladesh |
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Authors: | Sheikh Aleemuzzaman Sugitani Masahiko Kinukawa Noriko Moriyama Mitsuhiko Arakawa Yasuyuki Komiyama Kazuo Li Tian-Cheng Takeda Naokazu Ishaque Shamsuddin M Hasan Mahmud Suzuki Koyu |
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Institution: | Department of Pathology, Nihon University School of Medicine, Tokyo, Japan. sheikh@med.nihon-u.ac.jp |
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Abstract: | This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population. Sera from 22 FH patients were analyzed for antibodies to hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C and D viruses, and HEV and for hepatitis B surface antigen (HBsAg). Anti-HEV immunoglobulin M (IgM) was detected in the sera of 63.6% of patients, whereas 35.7% were positive for HBsAg. A high prevalence of HEV infection (83.3%) was noted in the HBV carriers. Serum samples from 273 apparently healthy individuals were tested for antibodies to HAV and HEV. Anti-HEV IgM was detected in 7.3% of the samples. The seroprevalence of HAV differed from that of HEV in the same population because all samples were negative for anti-HAV IgM. These data indicate that HEV infection is highly endemic in Bangladesh. |
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