小儿咳嗽变异性哮喘29例诊治体会

目的：比较酮替芬与孟鲁斯特钠治疗小儿咳嗽变异性哮喘的临床价值。方法：将咳嗽变异性哮喘29例分为酮替芬组15例、盖鲁斯特钠组14例。酮替芬组口服富马酸酮替芬治疗，3岁以内05mg／次，3岁以上1mg／次，1～2次／d。孟鲁斯特钠组口服孟鲁斯特钠治疗，2～5岁4mg，5～15岁5mg，1次／d。治疗时间最短1个月，反复发作者可治疗6个月～1年。结果：治疗1周后症状均明显改善或消失29例，服用酮替芬后睡眠时间延长4例，连续用药一周后恢复正常，服用丙卡特罗后心慌1例，停药后缓解。所有患儿监护人均诉服药期间上呼吸道感染后咳嗽天数较未服药时缩短，症状减轻。结论：孟鲁斯特钠和酮替芬治疗咳嗽变异性哮喘效果相似；酮替芬价格低廉、疗效确切，在社区儿科门诊应用于防治哮喘和过敏性咳嗽有重要地位。

Diagnosis and treatment of 29 cases of cough variant asthma in children

Objective ：To compare the clinical value of Ketotifen and Montelukast in the treatment of cough variant asthma in children. Meth- ods ：29 cases of cough variant asthma were divided into Ketotifen group（ 15 cases） and Montelukast group（ 14 cases）. Ketotifen group were given Ketotifen Fumarate, 〈 3 years old 0. 5mg/times, ≥3 years old 1 mg/times, 1 -2 times/d. Montelukast group were given Montelukast ,2 -5 years old 4mg,5 -- 15 years old 5mg, 1 times/d. The shortest duration of treatment of 1 months,repeatedly made for 6 months to I years. Results： After one week of treatment. symptoms were significantly improved or disappeared. Aafter taking Ketotifen,4 patients sleep time extension,returned to normal after continuous medica- tion a week ; after taking Procaterol, 1 patient had palpitation, relief of symptoms after stopping drug. Conclusion ： Montelukasl and Ketotifen have similar effects for treatment of cough variant asthma;Ketotifen is cheap,and has the exact effect.