| 蒽丹西酮合成新工艺反应机理的研究 |
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| 引用本文： | 黄文龙 周金培. 蒽丹西酮合成新工艺反应机理的研究[J]. 中国药科大学学报, 1999, 30(1): 1-2 |
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| 作者姓名： | 黄文龙 周金培 |
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| 作者单位： | 中国药科大学药物化学研究室 |
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| 摘 要： | 以咔唑酮（２）为原料通过一锅煮新工艺可直接制备蒽丹西酮。为研究其反应机理，先通过实验制备曼尼希反应中间体（３），再与咔唑酮反应制得蒽丹西酮（１），为新工艺的曼尼希反应机理提供了证据。
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| 关 键 词： | 蒽丹西酮；曼尼希反应；反应机理 |
Research on the Reaction Mechanism of Synthesis Ondansetron |
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| Huang Wenlong,Zhou Jinpei,Hua Weiyi Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing. Research on the Reaction Mechanism of Synthesis Ondansetron[J]. Journal of China Pharmaceutical University, 1999, 30(1): 1-2 |
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| Authors: | Huang Wenlong Zhou Jinpei Hua Weiyi Division of Medicinal Chemistry China Pharmaceutical University Nanjing |
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| Affiliation: | Huang Wenlong,Zhou Jinpei,Hua Weiyi Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | HT 3 receptor antagonist ondansetron can be prepared directly from 9 methyl 1,2,3,9 tetrahydro 4H carbazol 4 one(2) by new technology of one pot reaction. Mannich reaction intermediate 1 hydroxymethyl 2 methyl imidazole(3) was synthesized and reacted with compound(2) to produce ondansetron, which gave the proof that the new technology was of Mannich reaction mechanism. |
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| Keywords: | Ondansetron Mannich reaction Reaction mechanism |
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