Cryoimmunology for malignant bone and soft-tissue tumors |
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Authors: | Hideji Nishida Norio Yamamoto Yoshikazu Tanzawa Hiroyuki Tsuchiya |
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Institution: | (1) Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan |
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Abstract: | Several new methods have recently been developed for the treatment of malignant bone and soft-tissue tumors, and many of these
targeted therapies have yielded promising initial results in clinical settings. As more sarcomas become amenable to effective
molecular-targeting therapy, the need to evaluate the synergistic effects of combination therapies with anticancer drugs will
grow. Other immunologic therapies have also been reported, such as exogenous cytokines, dendritic cell (DC) therapy and peptide
vaccines. Cryoimmunology has shown promising results in some malignant tumors after cryosurgery and is expected to influence
the next generation of tumor immunotherapy. In this report, we describe the induction of a systemic antitumor immune response
following liquid nitrogen cryotreatment of a destructive murine osteosarcoma. Combining tumor cryotreatment with DCs to promote
tumor-specific immune responses enhanced systemic immune responses and inhibited metastatic tumor growth. We also describe
the induction of a systemic antitumor immune response following reconstruction for malignant bone tumors using frozen autografts
treated with liquid nitrogen. |
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